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The impact of air pollution control measures and the COVID-19 pandemic on photosynthesis in urban trees.
Sci Rep
January 2025
Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.
Phytotoxic air pollutants such as atmospheric nitrogen dioxide (NO) are among the major stresses affecting tree photosynthesis in urban areas. We clarified the relationship between NO concentrations and photosynthetic function for three major urban trees, Prunus × yedoensis, Rhododendron pulchrum, and Ginkgo biloba, planted in Kyoto and surrounding cities, combining our published data and new data collected from 2020 to 2023. High NO increased long-term water use efficiency for all species.
View Article and Find Full Text PDFGuidelines for Accurate and Precise Stable Isotope Analysis of Calcite, Dolomite, and Magnesite Using a Carbonate Device for Continuous Flow-Isotope Ratio Mass Spectrometry (CF-IRMS).
Rapid Commun Mass Spectrom
March 2025
School of Earth, Environment & Society, McMaster University, Hamilton, Ontario, Canada.
Rationale: Carbonate minerals are one of the most popular samples for an automated sample preparation system for CF-IRMS, such as GasBench II and iso FLOW, but no standardized analytical protocols exist. This study gives guidelines on optimal analytic conditions for carbon and oxygen isotope analysis of Ca-Mg carbonates when using the carbonate-phosphoric acid reaction method.
Methods: Calcite (CaCO-McMaster Carrara), dolomite (CaMg(CO)-MRSI Dolomite), and magnesite (MgCO-ROM Brazil Magnesite) with two grain size fractions (< 74 and 149-250 μm) were reacted with 103% (specific gravity of 1.
Biomarkers.
Alzheimers Dement
December 2024
Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.
Background: To evaluate the in vitro binding properties of [C]PiB and [F]NAV4694 head-to-head in post-mortem human brain tissue.
Method: Autoradiography was used to assess uptake of [C]PiB and [F]NAV4694 in control (CN) and Alzheimer's disease (AD) autopsy-confirmed brain tissues. The study focuses on the analysis of the prefrontal cortex, inferior parietal cortex, posterior cingulate cortex and hippocampus sections in 11 CN and 11 AD cases.
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: The G protein-coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer's disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn) processes triggers metallic dyshomeostasis, oxidative stress, neuroinflammation, microtubule destabilization, synaptic dysfunction, and tau phosphorylation-all hallmarks of neurodegeneration. Hence, pharmacologic modulation of GPR39 could offer an effective treatment against AD and ADRD.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Although associated with early changes in Aβ and tau formations, microtubule (MT) destabilization has not yet been systematically evaluated as an early biomarker of neurodegeneration and a tool to quantify it in real-time could provide information on these early changes in AD cascade. While current Aβ and tau PET approaches can characterize disease lesions, they fall short in capturing earlier molecular events. Our team development the first brain-penetrant MT PET ligand, [C]MPC-6827.
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