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Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial.
J Clin Oncol
December 2024
NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Article Synopsis
- This clinical trial tested the effectiveness of an oral cannabis extract (THC:CBD) on adults experiencing severe nausea and vomiting from chemotherapy, despite using standard anti-nausea medications.
- The results showed that the cannabis extract significantly increased the rate of complete responses (no vomiting or need for rescue meds) from 8% to 24% compared to a placebo.
- While participants reported some mild side effects like sedation and dizziness, there were no serious adverse events linked to the cannabis treatment.
Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia.
Front Psychiatry
March 2024
Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
Schizophrenia is a complex condition with entwined genetic and epigenetic risk factors, posing a challenge to disentangle the intermixed pathological and therapeutic epigenetic signatures. To resolve this, we performed 850K methylome-wide and 700K genome-wide studies on the same set of schizophrenia patients by stratifying them into responders, non-responders, and drug-naïve patients. The key genes that signified the response were followed up using real-time gene expression studies to understand the effect of antipsychotics at the gene transcription level.
View Article and Find Full Text PDFEffect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine (Baltimore)
March 2024
Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
Article Synopsis
- Lipid emulsion has been found to be effective in treating serious cardiovascular issues caused by toxic levels of certain neuropsychiatric drugs, particularly those that are lipophilic (fat-soluble).
- A study analyzed case reports to evaluate how lipid emulsions impacted patient recovery based on the Glasgow Coma Scale and corrected QT intervals, focusing on specific drugs like amitriptyline and trazodone.
- Results showed that 98.3% of patients improved with lipid emulsion treatment, although more research is necessary to fully understand its effects and optimize its use.
Inpatient Management of Hyperemesis Gravidarum.
Obstet Gynecol
June 2024
University of Texas Medical Branch at Galveston, Galveston, Texas.
Hyperemesis gravidarum has a reported incidence of approximately 0.3-3% of pregnancies. Without treatment, refractory hyperemesis gravidarum can result in dehydration, electrolyte deficiencies, and severe nutritional deficiencies, resulting in significant maternal morbidity.
View Article and Find Full Text PDFThe Challenge of Managing Refractory Psychosis Amid Multiple Medication Side Effects: A Case Report and Review of the Literature.
Cureus
December 2023
Psychiatry, Memorial Regional Hospital, Hollywood, USA.
Antipsychotics are the mainstay for the treatment of schizophrenia and other psychotic disorders; however, these agents are associated with an extensive side effect profile that may complicate treatment outcomes. We present the case of a 35-year-old woman with a history of schizoaffective disorder and five prior psychiatric hospitalizations. The patient first presented to the hospital for disorganized behavior, in addition to poor sleep, auditory hallucinations, and racing thoughts in the context of medication nonadherence.
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