Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who also failed a prospective trial of nortriptyline. We enrolled 92 subjects with treatment resistant depression. Treatment resistance was defined by at least one, but no more than five, adequate trials of antidepressants during the current episode. Subjects were treated with nortriptyline (NT) for 6 weeks. Those subjects who tolerated NT for 6 weeks and whose depression did not respond (n=35) were randomized to receive either lithium (n=18) or placebo (N=17) augmentation of nortriptyline for an additional 6 weeks. Response was defined as an equal to or greater than 50% decrease in HAM-D-17 scores. After 6 weeks of double-blind augmentation, 12.5 % of subjects responded to lithium and 20.0% to placebo. Our results revealed no significant difference between lithium and placebo augmentation. While lithium augmentation seems to be useful in depression refractory to a single medication in some studies, our data suggest limited usefulness of this option for patients refractory to multiple treatments. More definitive data await the outcome of the NIMH Sequential Treatment Alternatives to Relieve Depression (STAR*D) study.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/00004714-200302000-00013 | DOI Listing |
Discov Nano
December 2024
School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, People's Republic of China.
LiTiO (LTO) batteries are known for safety and long lifespan due to zero-strain and stable lattice. However, their low specific capacity and lithium-ion diffusion limit practical use. This study explored modifying LTO through yttrium doping by hydrothermal method to form LiYTiO nanoparticles.
View Article and Find Full Text PDFCells
November 2024
Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 2000 E Kenwood Blvd, Milwaukee, WI 53211, USA..
Enhancement of neuronal plasticity by small-molecule therapeutics protects cognitive skills and also ameliorates progressive neurodegenerative pathologies like Alzheimer's disease (AD) and dementia. One such compound, a novel histone deacetylase 2 (HDAC2) inhibitor named JRM-28, was shown here to enhance dendritic strength, augment spine density, and upregulate post-synaptic neurotransmission in hippocampal neurons. The molecular basis for this effect correlates with JRM-28-induced upregulation of the transcription of cAMP response element-binding protein(CREB), induction of its transcriptional activity, and subsequent stimulation of expressions of CREB-dependent plasticity-associated genes, such as those encoding N-methyl-D-aspartate (NMDA) receptor subunit NR2A and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1.
View Article and Find Full Text PDFJ Mol Neurosci
December 2024
Molecular and Cell Biology Unit, Poznan University of Medical Sciences, Poznan, Poland.
Depression is a common disease that affects 3.8% of the global population. Despite various antidepressant treatments, one-third of patients do not respond to antidepressants, therefore augmentation with mood stabilizers such as lithium may be required in this group.
View Article and Find Full Text PDFCarbohydr Polym
February 2025
Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
The titanium-based lithium ion sieve (HTO), renowned for its exceptional adsorption performance and cyclic stability, was utilized in addressing the global shortage of lithium resources. However, the recovery and reuse efficiency of HTO in powder form is relatively low, which limits its application in industrial fields. To address this issue, this study utilized carboxymethyl cellulose (CMC) as the principal matrix material, while polyvinyl alcohol (PVA) played a dual function as both matrix and crosslinker, negating the necessity for supplementary crosslinking materials.
View Article and Find Full Text PDFJ Mol Model
November 2024
College of New Energy, Xi'an Shiyou University, Xi'an, 710065, China.
Context: Battery interface research can effectively guide battery design and material selection to improve battery performance. However, current electrode material interface studies still have significant limitations. In this paper, by employing DFT-D method, the influences of doping elements (boron, nitrogen, phosphorus, sulfur, and silicon) on the properties of C fullerene, such as structural stability, electronic properties, and the adsorption and migration of lithium ion, are comprehensively investigated.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!