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Role of immune-checkpoint LAG3 as a biomarker finding tool in patient-derived organoid cultures of breast cancer.
Sci Rep
December 2024
IRCCS SYNLAB SDN, Naples, 80143, Italy.
LAG3 plays a regulatory role in immunity and emerged as an inhibitory immune checkpoint molecule comparable to PD-L1 and CTLA-4 and a potential target for enhancing anti-cancer immune responses. We generated 3D cancer cultures as a model to identify novel molecular biomarkers for the selection of patients suitable for α-LAG3 treatment and simultaneously the possibility to perform an early diagnosis due to its higher presence in breast cancer, also to achieve a theragnostic approach. Our data confirm the extreme dysregulation of LAG3 in breast cancer with significantly higher expression in tumor tissue specimens, compared to non-cancerous tissue controls.
View Article and Find Full Text PDFExplainable artificial intelligence for stroke prediction through comparison of deep learning and machine learning models.
Sci Rep
December 2024
Artificial Intelligence in Medical Sciences Research Center, Smart University of Medical Sciences, Tehran, Iran.
Failure to predict stroke promptly may lead to delayed treatment, causing severe consequences like permanent neurological damage or death. Early detection using deep learning (DL) and machine learning (ML) models can enhance patient outcomes and mitigate the long-term effects of strokes. The aim of this study is to compare these models, exploring their efficacy in predicting stroke.
View Article and Find Full Text PDFAntenatal detection of pediatric surgical congenital abnormalities and its effect on maternal anxiety: a multicentre prospective study in a middle-income country.
Pediatr Surg Int
December 2024
Division of Paediatric & Neonatal Surgery, Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Background: In middle-income countries, healthcare systems face unique challenges in ensuring timely antenatal detection of congenital abnormalities that require pediatric surgical intervention. Early detection can significantly improve outcomes, yet resource constraints often limit access to diagnostic technologies. This study evaluates the antenatal detection rate of congenital abnormalities referred to pediatric surgical services in three Malaysian tertiary centers and examines its effect on maternal anxiety.
View Article and Find Full Text PDFResearch on water immersion damage characteristics and equivalent width of coal pillar.
Sci Rep
December 2024
College of Energy Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China.
Affected by weakening effect of water in the goaf, the bearing capacity of coal pillar reduced, and coal pillar rock burst is prone to occur, which is a serious threat to mine safety in production. In order to study the equivalent width and stability of coal pillar in water-rich coal seam, taking the section coal pillar of a working face as the research object, combined with laboratory test, theoretical analysis, simulation and engineering practice, the stress, elastic core area width, damage degree and energy accumulation of 36 m water-immersed coal pillar and 26 m, 28 m, 30 m, 32 m, 36 m unimmersed coal pillars are analyzed. The research results show that: (1) The reasonable width of coal pillar under flooded and unflooded conditions is 36.
View Article and Find Full Text PDFA new diminutive species of bohaiornithid enantiornithine (Aves: Ornithothoraces) from the Lower Cretaceous Jehol Group, northern China.
Sci Rep
December 2024
Negaunee Integrative Research Center, Field Museum, 1400 S. Dusable Lake Shore Drive, Chicago, IL, 60605, USA.
Enantiornithes are the most successful early-diverging avian clade, their fossils revealing important information regarding the structure of Cretaceous avifaunas and the parallel refinement of flight alongside the ornithuromorph lineage that includes modern birds. The most diverse recognized family of Early Cretaceous enantiornithines is the Bohaiornithidae, known from the Jehol Biota in northeastern China. Members of this clade enhance our understanding of intraclade morphological diversity and elucidate the independent evolution of this unique lineage.
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