We have developed a rapid new in vivo method for screening experimental drugs for their activity against Mycobacterium tuberculosis by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of active compounds can be seen after only 8 days of treatment. To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151769 | PMC |
| http://dx.doi.org/10.1128/AAC.47.2.783-785.2003 | DOI Listing |
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