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A retrospective cohort study of monthly rifampicin, ofloxacin and minocycline in the management of leprosy at the Hospital for Tropical Diseases, London, United Kingdom.
PLoS Negl Trop Dis
December 2024
Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Introduction: The World Health Organization (WHO) recommends rifampicin, dapsone and clofazimine multi-drug therapy (MDT) for the treatment of leprosy. Severe adverse effects include dapsone hypersensitivity syndrome, skin pigmentation, haemolytic anaemia, and hepatitis. At the Hospital for Tropical Diseases (HTD), London, United Kingdom monthly rifampicin, ofloxacin and minocycline (mROM) is used as first line treatment for leprosy.
View Article and Find Full Text PDFCXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain.
Brain Behav Immun
January 2025
Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- Pancreatic cancer can lead to severe abdominal pain, and while peripheral mechanisms have been explored, the involvement of the central nervous system, specifically the nucleus tractus solitarii (NTS), remains less understood.
- Researchers found that in mice experiencing pancreatic cancer-induced pain, neurons in the NTS showed increased activity and excitability, alongside signs of neuroinflammation and microglia activation.
- Intervention using a microglia inhibitor or blocking the CXCL1-CXCR2 signaling pathway significantly reduced pain symptoms, suggesting that the activation of microglia in the NTS plays a crucial role in mediating this pain response.*
Microglia-dependent peripheral neuropathic pain in adulthood following adolescent exposure to morphine in male rats.
Neuropharmacology
February 2025
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Institute for Brain and Cognition, Tarbiat Modares University, Tehran, Iran. Electronic address:
Persistent effects of adolescent morphine exposure on neurobiological processes and behaviors in adulthood have been partially identified. Hypersensitivity following adolescent exposure to morphine is a complex and multifaceted phenomenon whose underlying mechanisms remain largely unknown. This study aimed to investigate the involvement of microglia in neuropathic pain sensitivity following adolescent morphine exposure, focused on hippocampal genes expression and plasticity.
View Article and Find Full Text PDFIn vivo imaging identified efficient antimicrobial treatment against Mycobacterium marinum infection in mouse footpads.
Sci Rep
October 2024
Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Aoba-cho, Higashimurayama, Tokyo, Japan.
Article Synopsis
- Mycobacterium marinum is a leading cause of non-tuberculous mycobacterial infections, notably fish tank granuloma, and is more resistant to treatments compared to other NTM bacteria.
- Current treatment protocols for M. marinum are not well-established, and few studies have investigated how effective existing antibiotics are in living mammals.
- The study introduced a noninvasive imaging method to track M. marinum infections in mice, revealing that a combination of specific antibiotics helped clear the infection, while also highlighting the role of immune responses in granuloma development similar to tuberculosis.
Sildenafil-induced drug reaction with eosinophilia and systemic symptoms.
Urol Case Rep
July 2024
Department of Dermatology, Military Hospital, Tunis, Tunisia.
Drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) is a life-threatening, multi-organ adverse drug reaction with a mortality rate of approximately 10 %-20 %. The most common culprit drugs are anticonvulsants, some antibiotics such as dapsone and minocycline, salazosulfapyridine, allopurinol and some antiretroviral molecules such as abacavir and nevirapine. Only one case of DRESS induced by sildenafil has been reported in the literature.
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