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Int J Pharm
January 2025
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong. Electronic address:
Cocrystallization has emerged as a promising formulation strategy for modulating transdermal drug absorption by enhancing solubility and permeability. However, challenges related to cocrystal dissociation in the semi-solid state need to be addressed to mitigate regulatory concerns before the widespread implementation of topical cocrystal products in clinical practice. This study aimed to develop oil-based topical formulations incorporating cocrystals with distinct thermodynamic stabilities, followed by investigating the roles of different structurally similar coformers and oily vehicles on their physicochemical properties.
View Article and Find Full Text PDFPharmaceutics
August 2024
Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.
Premature loss of root canal-treated primary teeth has long been a concern in dentistry. To address this, researchers developed a sodium iodide-based root canal-filling material as an alternative to traditional iodoform-based materials. The goal of this study was to improve the physicochemical properties of the sodium iodide-based material to meet clinical use standards.
View Article and Find Full Text PDFPak J Pharm Sci
November 2022
Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Istanbul, Turkiye.
Propolis is a resinous substance containing aromatic acids, esters, volatile compounds, hydrocarbons, steroids, enzymes, flavonoids, vitamins and minerals. In this direction it has nutrient, antibacterial and antioxidant properties due to its complex structure and content. In this study it was aimed to prepare a propolis ointment with a base of occlusive and emollient properties for nourishing and healing of skin damaged by environmental effects.
View Article and Find Full Text PDFProtein Sci
December 2022
Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.
Sphingomonas paucimobilis' P450 (CYP152B1) is a good candidate as industrial biocatalyst. This enzyme is able to use hydrogen peroxide as unique cofactor to catalyze the fatty acids conversion to α-hydroxy fatty acids, thus avoiding the use of expensive electron-donor(s) and redox partner(s). Nevertheless, the toxicity of exogenous H O toward proteins and cells often results in the failure of the reaction scale-up when it is directly added as co-substrate.
View Article and Find Full Text PDFJ Oleo Sci
October 2020
Çanakkale Onsekiz Mart University, Faculty of Engineering, Department of Food Engineering.
This study was aimed to prepare oleogels of whale spermaceti wax (WsWO) and lanolin wax (LnWO), and to compare them with well-known animal wax oleogels of shellac (ShWO) and beeswax (BsWO). WsWO, ShWO and BsWO were prepared at 5% (w/w) organogelator addition level, while LnWO was necessarily prepared at its minimum gelling concentration (C*) of 30% (w/w) addition level. All oleogels were posed high oil binding capacity and thermal reversibility.
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