Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3785/j.issn.1008-9292.2002.02.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Agonists of the opioid δ-receptor improve irritable bowel syndrome-like symptoms via the central nervous system.
Br J Pharmacol
December 2024
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Background And Purpose: Irritable bowel syndrome (IBS) is a common condition that is challenging to treat, and novel drugs are needed for this condition. Previously, a chronic vicarious social defeat stress (cVSDS) mouse model exhibits IBS-like symptoms. Also agonists of the opioid δ-receptor exert anti-stress effects in rodents with minimal adverse effects.
View Article and Find Full Text PDFCircadian rhythm disruption modulates enteric neural precursor cells differentiation leading to gastrointestinal motility dysfunction via the NR1D1/NF-κB axis.
J Transl Med
October 2024
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objectives: Circadian rhythm disruption (CRD) is implicated with numerous gastrointestinal motility diseases, with the enteric nervous system (ENS) taking main responsibility for the coordination of gastrointestinal motility. The purpose of this study is to explore the role of circadian rhythms in ENS remodeling and to further elucidate the underlying mechanisms.
Methods: First, we established a jet-lagged mice model by advancing the light/dark phase shift by six hours every three days for eight weeks.
Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion . Disruptions in microbial communities caused by antibiotics or enteric infections result in the loss of enteric neurons and long-term motility disorders . However, the signals and underlying mechanisms of this microbiota-neuron communication are unknown.
View Article and Find Full Text PDFTherapeutic approaches in Hirschsprung's disease: clinical cases.
J Med Life
June 2024
Department of Pharmaceutical Sciences, Vasile Goldiş Western University of Arad, Arad, Romania.
Article Synopsis
- Hirschsprung's disease is a condition babies can be born with where certain nerve cells are missing from the intestines, causing problems with digestion and constipation.
- It happens in about 1 in 5,000 newborns and is more common in boys.
- Treatment usually involves surgery to remove the part of the intestine that doesn't work right, with special care after surgery to help kids get better and live healthier lives.
Fabrication of 3D Biomimetic Smooth Muscle Using Magnetic Induction and Bioprinting for Tissue Regeneration.
Biomater Res
September 2024
Health Science Center, Ningbo University, Ningbo 315211, China.
Article Synopsis
- * Current scaffold designs primarily focus on two-dimensional cell alignment, failing to achieve the necessary three-dimensional structure needed to restore muscle function.
- * The introduction of an iron oxide-embedded hydrogel that promotes 3D cell alignment and differentiation shows promise for improving muscle tissue regeneration and connectivity, offering an innovative solution for treating muscle-related diseases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!