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Hyperhomocysteinemia: Underlying Links to Stroke and Hydrocephalus, with a Focus on Polyphenol-Based Therapeutic Approaches.
Nutrients
December 2024
Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen Macarena, CSIC, Universidad de Sevilla, 41004 Sevilla, Spain.
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (HCys) levels, is associated with increased risks of neurovascular diseases such as stroke or hydrocephalus. HHcy promotes oxidative stress, neuroinflammation, and endothelial dysfunction, disrupting the blood-brain barrier and accelerating neurodegeneration. These processes highlight HCys as both a biomarker and a potential therapeutic target in vascular-related neurological disorders.
View Article and Find Full Text PDFIntegrative in-silico and in-vitro analysis of taurine and vitamin B12 in modulating PPARγ and Wnt signaling in hyperhomocysteinemia-induced osteoporosis.
Biol Direct
December 2024
School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Peroxisome proliferator-activated receptor-γ (PPARγ) is a critical regulator of adipogenesis and bone metabolism, playing complex roles in osteoporosis. This study investigates the effects of taurine and homocysteine on PPARγ, focusing on their roles in osteoclastogenesis and bone health. In-silico analyses, including molecular docking and molecular dynamic simulations, revealed that both taurine and homocysteine bind competitively to the PPARγ ligand-binding domain, exhibiting distinctive antagonistic modes, including destabilization of PPARγ's key helices H3, H4/5, H11, and H12.
View Article and Find Full Text PDFHigh penetrance and phenotypic landscape of methylenetetrahydrofolate reductase c.665 C>T polymorphism in the absence of folate fortification.
Clin Nutr ESPEN
November 2024
Yoda Diagnostics Pvt Ltd, 6-3-862/A, Lal Bungalow add on, Ameerpet, Hyderabad, India. Electronic address:
Article Synopsis
- * Analysis involved 2,431 cases and 1,265 healthy controls, revealing that individuals with the MTHFR variant had a significantly higher risk for conditions like respiratory distress, recurrent pregnancy loss, and intellectual disabilities.
- * The MTHFR TT-genotype specifically indicated a high risk of abnormal phenotypes, emphasizing the importance of this genetic variant in neurodevelopmental and other health-related outcomes.
Exploring the effects of homocysteine metabolism in osteoporosis management in Indian adult females.
Int J Mol Epidemiol Genet
October 2024
Department of Biochemistry, Faculty of Science, University of Allahabad Prayagraj 211002, Uttar Pradesh, India.
Women are at a significantly higher risk of osteoporotic fractures, largely due to progressive bone demineralization and impaired bone microarchitecture. Low bone mineral density (BMD) is a common condition in women worldwide. Disrupted homocysteine (Hcy) metabolism has been linked to reduced BMD and increased risk of osteoporotic fractures.
View Article and Find Full Text PDFHyperhomocysteinemia Causing Vascular Occlusion and Complicated by Heparin-Induced Thrombocytopenia and Gastrointestinal Bleed.
Cureus
October 2024
General Surgery, Western Reserve Health Education, Northeast Ohio Medical University (NEOMED), Warren, USA.
Homocysteine, an intermediate amino acid, is involved in methionine metabolism, which is crucial for various physiological pathways, including protein synthesis and DNA methylation. Elevated levels of homocysteine have been implicated as both a modifiable and unmodifiable risk factor in cardiovascular disease, influencing atherosclerotic disease formation and hypercoagulability. Mechanisms linking elevated homocysteine levels to vascular occlusion involve endothelial dysfunction, inflammation, and enhanced thrombotic potential.
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