We have used a first-order reflectron lens in an optical tomographic atom probe in order to improve the mass resolution. Calculations have been performed to determine the effect of second-order errors in ion energy and incidence angle on the performance of the lens. By applying a correction procedure based on the results of these calculations, we have been able to improve experimental mass resolution by 30%.
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http://dx.doi.org/10.1016/s0304-3991(02)00321-2 | DOI Listing |
Anal Chim Acta
January 2025
College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea. Electronic address:
Background: The simplicity of synthesis methods has facilitated the illegal manufacture of various fentanyl analogs, leading to numerous fatal overdoses worldwide, particularly in North America. Fentanyl analogs with similar structures are difficult to distinguish due to their fragmentation patterns, making separation using chromatography essential. Additionally, because fentanyl analogs are lethal even in trace amounts, they are easily smuggled, and commonly used fentanyl test strips often fail to detect them due to their low sensitivity.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
School of Environmental Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 611756, China. Electronic address:
Although hydroxyl radicals (OH) degrade organic pollutants nonselectively, their mineralization rate during the treatment of waste leachate biological treatment effluent (BTL) using Fenton or Fenton-like systems is not high, and the reason is unknown. In this study, we investigated three typical Fenton-like systems that act on dissolved organic matter (DOM) in BTL. We analyzed the molecular composition of DOM resistant to OH, using ultrahigh resolution mass spectrometry.
View Article and Find Full Text PDFForensic Sci Int
January 2025
Laboratoire de Pharmacologie - Toxicologie, CHU de Saint-Etienne, Saint-Etienne, France; INSERM, UMR 1059, Dysfonction Vasculaire et de l'Hémostase, Université de Lyon, Saint-Etienne, France. Electronic address:
3-Chloromethcathinone (3-CMC) is a synthetic cathinone that has been identified as a new psychoactive substance (NPS) by the European Monitoring Centre for Drugs and Drug Addiction. Despite its increasing prevalence in the recreational drug market since 2014, scientific literature on 3-CMC remains limited. This study employed a multi-step approach to investigate 3-CMC metabolism.
View Article and Find Full Text PDFArch Toxicol
January 2025
Department of Biochemistry and Microbiology, University of Chemistry and Technology, Technická 3, 16000, Prague, Czech Republic.
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlorinated paraffins (SCCPs) has been restricted since 2017, the use of medium-chain chlorinated paraffins (MCCPs) has risen as their replacement. Due to lipophilic character, it can be expected that CPs enter the cells; however, the in vitro accumulation potential of CPs remains poorly understood.
View Article and Find Full Text PDFAnal Chim Acta
January 2025
Christian Doppler Laboratory for Innovative Gut Health Concepts of Livestock, Austria; BOKU University, Vienna, Dept. IFA-Tulln, Institute of Bioanalytics and Agro-Metabolomics, Tulln, Austria.
Background: Untargeted metabolomics requires robust and reliable strategies for data processing to extract relevant information form the underlying raw data. Multiple platforms for data processing are available, but the choice of software tool can have an impact on the analysis. This study provides a comprehensive evaluation of four workflows based on commonly used metabolomics software tools: XCMS, Compound Discoverer, MS-DIAL, and MZmine.
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