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Neuroinflammatory Pathways Associated with Chronic Post-Thoracotomy Pain: A Review of Current Literature.
Mol Neurobiol
October 2024
Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Chronic post-thoracotomy pain (CPTP) is a major clinical problem that affects up to 35-55% of patients undergoing thoracic incisions. Evidence suggests that multiple cellular signaling pathways and neuro-inflammatory mediators may play an essential role in the pathogenesis of CPTP. In this comprehensive review, we present the current evidence on the cellular signaling pathways and inflammatory changes associated with the initiation and maintenance of CPTP, focusing on the potential application of these findings in the clinical setting.
View Article and Find Full Text PDFADCY5 act as a putative tumor suppressor in glioblastoma: An integrated analysis.
Heliyon
September 2024
Department of Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, China.
Article Synopsis
- This research focuses on the role of the ADCY5 gene in glioblastoma (GBM), examining its expression, epigenetic changes, and how these factors impact patient prognosis.
- ADCY5 was found to be downregulated in GBM tissues and cell lines, and its lower expression correlates with higher DNA methylation and poorer patient outcomes.
- Restoring ADCY5 expression reduced GBM cell growth and migration, indicating its potential as a therapeutic target in combating GBM.
Fundamentals and Translational Applications of Stem Cells and Biomaterials in Dental, Oral and Craniofacial Regenerative Medicine.
Crit Rev Eukaryot Gene Expr
June 2024
Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
Regenerative dental medicine continuously expands to improve treatments for prevalent clinical problems in dental and oral medicine. Stem cell based translational opportunities include regenerative therapies for tooth restoration, root canal therapy, and inflammatory processes (e.g.
View Article and Find Full Text PDFMyeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis.
Int J Biol Sci
April 2024
State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wnt/β-catenin signaling plays a pivotal role in the pathogenesis of chronic kidney diseases (CKD), which is associated with macrophage activation and polarization. However, the relative contribution of macrophage-derived Wnts in the evolution of CKD is poorly understood. Here we demonstrate a critical role of Wnts secreted by macrophages in regulating renal inflammation and fibrosis after various injuries.
View Article and Find Full Text PDFWnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.
JBMR Plus
May 2024
Department of Medicine, Division of Endocrinology and Metabolism, The Institute for Human Genetics, and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, United States.
G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including the development, remodeling, and repair of the skeleton. Fibrous dysplasia (FD) of the bone is characterized by fibrotic, expansile bone lesions caused by activating mutations in There are no effective therapies for FD. We previously showed that ColI(2.
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