Disagreeable affect of fear or anxiety can form the essential of the epileptic critical semiology. The centrum seat is most often found to be temporal and in some rare cases frontal. This form of epilepsy makes it sometimes difficult to establish a differential diagnosis specially when confronted with panic attack. A careful semiologic analysis is needful. Some clinical criteria are in favor of an epileptic etiology like the shortness of the crises, the stereotyped characteristic of the semiology or the association with some other epileptic symptoms. The assumption of neurophysiologic substratum common to both entities is put forward by the authors. Indeed, the current researches are moving towards the likelihood that the limbic structures are stimulated by the epileptic discharge. These structures are taking a part in the pathogeny of the anxiety troubles. Three clinical vignettes are illustrating the difficulties in diagnosing this form of epilepsy.
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Seizure
January 2025
Health Services Vocational School, Artvin Coruh University, Artvin, Turkey. Electronic address:
Objective: This study determined the mediating role of knowledge about epilepsy in the relationship between attitudes toward epilepsy and health literacy in Turkey.
Methods: This descriptive and cross-sectional study was conducted in Turkey with 4,393 participants. The sociodemographic form, Epilepsy Attitude Scale, Epilepsy Knowledge Scale, and Health Literacy Scale were used for data collection.
Seizure
January 2025
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, PR China; Institute of Brain Science and Brain-Inspired Technology of West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China. Electronic address:
Background: The etiology of status epilepticus (SE) in Tibet has not yet been reported. We aimed to establish the etiological baseline of SE in the Tibet Autonomous Region in China and compare it with a SE cohort from a regional neuroscience centre in Sichuan, Southwestern China to reveal whether there was a unique etiology distribution in the Tibetan region.
Methods: We retrospectively captured clinical data of patients diagnosed with SE in the People's Hospital of Xizang Autonomous Region from January 2015 to December 2020.
Int J Mol Sci
January 2025
State Key Laboratory of Virology and Biosafety, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
HERVs (Human endogenous retroviruses) are remnants of ancient exogenous retroviruses that have integrated into the human genome, particularly in germ-line cells. Among these, the envelope protein gene (Human endogenous retroviruses W family envelope protein), located on chromosome 7 and primarily expressed in the human placenta, has been closely linked to various neuropsychiatric disorders, including schizophrenia, as well as autoimmune diseases and cancer. Recent studies have highlighted the abnormal expression of cytokines as a key factor in the pathophysiology of schizophrenia.
View Article and Find Full Text PDFDiseases
January 2025
Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Background: Acute myeloid leukemia (AML) is a common and aggressive form of leukemia, yet current treatment strategies remain insufficient. Venetoclax, a BH3-mimetic approved for AML treatment, induces Bcl-2-dependent apoptosis, though its therapeutic efficacy is still limited. Therefore, new strategies to enhance the effect of venetoclax are highly sought.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, King Abdulaziz Specialist Hospital, Taif, SAU.
Cerebral palsy (CP) is a debilitating disorder that can lead to life-long disability, with a high incidence in Saudi Arabia. Secondary epilepsy and cardiac complications are common in CP patients. We present a rare case of a 17-year-old female with CP, attention-deficit hyperactivity disorder (ADHD), secondary epilepsy, and a history of post-cardiac arrest, with home medications carbamazepine, risperidone, and sodium valproate.
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