Protective effect of enterosgel on rat liver lysosomes during cytostatic treatment.

Bull Exp Biol Med

Department of Pharmacology, Central Research Laboratory, Novosibirsk State Medical Academy.

Published: October 2002

Polychemotherapy with a complex of cytostatics (cyclophosphamide, doxorubicin, vincristine, prednisolone) induces progressive damage to hepatocyte membranes, which manifested in labilization of lysosomes and activation of lysosomal enzymes and serum transaminases. Enterosgel stabilized liver lysosomes and reduced manifestation of hepatocyte cytolysis.

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http://dx.doi.org/10.1023/a:1021904230328DOI Listing

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