Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore.

Emerg Infect Dis

Virology Laboratory, Department of Pathology, Singapore General Hospital, Outram Road, Singapore.

Published: January 2003

Singapore experienced a large epidemic of hand, foot and mouth disease (HFMD) in 2000. After reviewing HFMD notifications from doctors and child-care centers, we found that the incidence of HFMD rose in September and declined at the end of October. During this period, 3,790 cases were reported. We performed enteroviral cultures on 311 and 157 specimens from 175 HFMD patients and 107 non-HFMD patients, respectively; human enterovirus 71 (HEV71) was the most frequently isolated virus from both groups. Most of the HFMD patients were

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873753PMC
http://dx.doi.org/10.3201/eid0901.020112DOI Listing

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