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Gelatin-Modified Bioactive Glass for Treatment of Dentin Hypersensitivity.
Int J Mol Sci
November 2024
School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Article Synopsis
- Dentin hypersensitivity occurs when exposed dentin, often due to a lack of enamel, reacts to external stimuli, causing discomfort.
- A new treatment using gelatin-modified bioactive glass (MBG@PDA@Gel) effectively blocks dentin tubules and promotes mineralization, showing better results than the traditional agent Gluma in lab tests.
- Animal studies revealed that MBG@PDA@Gel not only remineralizes demineralized dentin effectively but also remains stable in the oral cavity, enhancing the biocompatibility of the material.
Background/objectives Dentine hypersensitivity (DH) is a common dental condition marked by transient, sharp pain arising from dentinal exposure. Bioactive materials are capable of remineralization. This study aims to explore the remineralization effect of bioactive glass (BAG) with and without fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), using dentine discs as the test substrate.
View Article and Find Full Text PDFEarly Biomarkers of Altered Renal Function and Orthostatic Intolerance During 10-day Bedrest.
Front Physiol
April 2022
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
Exposure to actual or simulated microgravity results in alterations of renal function, fluid redistribution, and bone loss, which is coupled to a rise of urinary calcium excretion. We provided evidence that high calcium delivery to the collecting duct reduces local Aquaporin 2 (AQP2)-mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration to reduce calcium saturation. To investigate early renal adaptation into simulated microgravity, we investigated the effects of 10 days of strict bedrest in 10 healthy volunteers.
View Article and Find Full Text PDFEffects of Calcium Source, Inulin, and Lactose on Gut-Bone Associations in an Ovarierectomized Rat Model.
Mol Nutr Food Res
April 2022
Department of Food Science, Aarhus University, Agro Food Park 48, Aarhus N, DK-8200, Denmark.
Scope: Osteoporosis poses a health challenge especially for postmenopausal women. This study aims to explore nutritional strategies to counteract bone demineralization in ovarierectomized (OVX) rats.
Methods And Results: OVX rats (n = 49) are fed with one of six different diets, where two different calcium sources (dairy calcium or calcium carbonate) are provided alone or in combination with either inulin (5%) or lactose (0.
6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis.
J Bone Miner Metab
November 2021
Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Corticotomy is widely used in clinical practice to accelerate tooth movement and shorten the duration of orthodontic treatment. It is effective, but an invasive surgery is needed to induce alveolar bone osteopenia that enable rapid tooth movement. In this study, we discovered the potential of 6-shogaol as a more patient-friendly non-invasive alternative to induce transient osteopenia and accelerate tooth movement.
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