AI Article Synopsis
- The paper discusses a new method for synthesizing nucleoside mimics by replacing the natural hydroxy groups of 2'-deoxythymidine or 2'-deoxyadenosine with thiol, amine, or alkylthiol groups.
- These modified nucleosides can form a DNA strand through metal coordination instead of typical internucleoside linkages.
- The study includes details about the structure and interaction of a specific compound, 3',5'-dithiothymidine, with gold (Au(I)).
Article Abstract
This paper describes a convenient synthetic procedure for nucleoside mimics, 1-6, in which the 3',5'-hydroxy groups of natural 2'-deoxythymidine or 2'-deoxyadenosine are replaced by thiol, amine, or alkylthiol groups. Such nucleosides would be built up into a single DNA strand with cooperative participation of metal coordination, where internucleoside linkages are replaced by metal complexation motifs. The X-ray crystal structure and complexation behaviors of 3',5'-dithiothymidine, 1, with Au(I) are also reported.
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| http://dx.doi.org/10.1021/jo026026l | DOI Listing |
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