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Osteoporosis: Causes, Mechanisms, Treatment and Prevention: Role of Dietary Compounds.
Pharmaceuticals (Basel)
December 2024
Department of Physiology, Faculty of Medicine, University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, 46010 Valencia, Spain.
Osteoporosis is a chronic disease that is characterized by a loss of bone density, which mainly affects the microstructure of the bones due to a decrease in bone mass, thereby making them more fragile and susceptible to fractures. Osteoporosis is currently considered one of the pandemics of the 21st century, affecting around 200 million people. Its most serious consequence is an increased risk of bone fractures, thus making osteoporosis a major cause of disability and even premature death in the elderly.
View Article and Find Full Text PDFBiomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement.
Int J Mol Sci
December 2024
Biotechnology Center, The Silesian University of Technology, 44-100 Gliwice, Poland.
Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used.
View Article and Find Full Text PDFEvaluation of the anti-spasmodic activity of essential oils of fruits and its main chemical component "perillaldehyde" on intestinal smooth muscle contractions of rodents: and approaches.
Front Chem
December 2024
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Ethnopharmacological Relevance: In Moroccan traditional medicine, plants from the Apiaceae family are widely utilized in folk medicine to treat various diseases associated with the digestive system. plays an important role as an antispasmodic that has been traditionally used, especially to treat digestive tract diseases in children.
Aim Of The Study: The aim of this research was to verify the traditional use by assessing the relaxant and spasmolytic activities of essential oil (ALEO) and then comparing them to the effects and potency of the major constituent of ALEO, which is perillaldehyde.
EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes.
Clin Chem Lab Med
January 2025
SKML, Nijmegen, The Netherlands.
Article Synopsis
- The EN ISO 15189:2022 standard updates regulations for medical laboratories, replacing previous versions and aiming for better quality and competence.
- The revision focuses on aligning with ISO/IEC 17025:2017, enhancing patient safety, and providing clearer guidelines while minimizing new requirements.
- A guidance document from the EFLM Committee has been produced to help laboratories and accreditation bodies understand and implement these changes effectively.
Advances in Functional Nucleic Acid SERS Sensing Strategies.
ACS Sens
January 2025
Center for Biomedical-photonics and Molecular Imaging, Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China.
Article Synopsis
- Functional nucleic acids differ from traditional methods by creating complex structures that enhance DNA interactions, allowing for more diverse applications.
- Recent advancements in functional DNA/RNA-based SERS (surface-enhanced Raman spectroscopy) have enabled highly sensitive and multiplex detection for various analytes.
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