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Causal Inference and Annotation of Phosphoproteomics Data in Multi-omics Cancer Studies.
Mol Cell Proteomics
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Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Protein phosphorylation plays a crucial role in regulating diverse biological processes. Perturbations in protein phosphorylation are closely associated with downstream pathway dysfunctions, while alterations in protein expression could serve as sensitive indicators of pathological status. However, there are currently few methods that can accurately identify the regulatory links between protein phosphorylation and expression, given issues like reverse causation and confounders.
View Article and Find Full Text PDFEvaluating oral health status in elderly Irula tribes of Tamil Nadu by using the Geriatric Oral Health Assessment Index.
J Family Med Prim Care
December 2024
Division of Epidemiology, SRM School of Public Health, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Introduction: Oral diseases are a significant global health issue, with over 3.5 billion cases worldwide. Caries and periodontitis are primary contributors to tooth loss, which not only incurs significant rehabilitation costs but also profoundly affects overall well-being.
View Article and Find Full Text PDFImpact of exposure to opioids in pregnancy on offspring developmental outcomes in the preschool years: an umbrella review.
BMJ Paediatr Open
January 2025
School of Health Sciences, University of Dundee, Dundee, UK
Background: Early child development sets the course for optimal outcomes across life. Increasing numbers of children worldwide are exposed to opioids in pregnancy and frequently live in environments associated with adverse developmental outcomes. Although multiple systematic reviews have been published in this area, they use different exposures and different types of outcomes.
View Article and Find Full Text PDFImpacts of Ramadan fasting during pregnancy on pregnancy and birth outcomes: An umbrella review.
Int J Gynaecol Obstet
January 2025
Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, Tennessee, USA.
Background: Despite a large number of primary research studies, and systematic and narrative reviews, there is no consensus on the impact of fasting during Ramadan while pregnant on pregnancy and birth outcomes. Currently, there is no evidence-based guideline for Muslim women regarding Ramadan fasting during pregnancy and clinicians cannot provide firm recommendations.
Objectives: To review the current evidence regarding the impact of Ramadan fasting during pregnancy on pregnancy and birth outcomes.
The association between domestic water hardness and kidney stone disease: a prospective cohort study from the UK Biobank.
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Department of Urology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Background: Kidney stone disease is a common surgical disease and significant public health issue, may be influenced by environmental factors such as domestic water hardness and its related minerals. Previous studies have shown inconsistent and controversial results regarding the impact of domestic water hardness on kidney stone formation.
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