AI Article Synopsis
- Aplysia siphon-withdrawal reflex demonstrates how synaptic plasticity helps with classical conditioning.
- By examining two cellular mechanisms—presynaptic facilitation and postsynaptic long-term potentiation—we gathered evidence that both are crucial for behavioral learning.
- Our findings indicate that these mechanisms interact with each other through retrograde signaling, rather than functioning independently.
Article Abstract
Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual neurons, we have provided the most direct evidence to date that each of these mechanisms contributes to behavioral learning. In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling.
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| http://dx.doi.org/10.1016/s0896-6273(02)01129-7 | DOI Listing |
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