"We never know.... Fate has a way of showing up at the most inopportune times. We had been planning for Ann's retirement for months. It was going to be a loss. Not only was she a long-term employee and strong manager, she could step in and lead anything. She would be sorely missed. We knew who was going to cover each of her areas of accountability. Sue would take one unit. John would manage the Dialysis Program. We had completed a job analysis, and everything was covered. We had already begun the shifting of accountabilities. September 2 was the big day. We had 3 months to go. Then the big opportunity came. We had been working on the merger for months before it finally happened. There was only one glitch. The culture shift was going to be huge. We needed someone to lead the process. Of course, who could do it better than Ann? She had been leading change for years. She was a master. She had the one skill for which we had no succession plan. We had one person that we could call, and within 3 months she would be gone. We had missed the mark. We had not completed our succession plan." These real-life stories show how critical succession planning can be to an organization. To do it well requires a clear vision of the strategic objectives of the organization, focused development programs, and continuous enrollment of both executives and employees within the organization. Leadership training, learning projects, and creating a coaching environment also are crucial elements of a successful succession plan.
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Environ Monit Assess
January 2025
School of Earth Sciences, Yunnan University, Kunming, 650500, China.
Rocky desertification (RD) is a severe phenomenon in karst areas, often referred to as "ecological cancer." However, studies on RD rarely include comparative analysis of different man-land relationship areas. This lack of analysis leads to difficulties in preventing and controlling RD in local areas with complex man-land relationships.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
College of Chemical and Environmental Engineering, Hanjiang Normal University, Shiyan 442000, China. Electronic address:
Adv Healthc Mater
January 2025
Department of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers a promising solution to the persistent challenges in colorectal cancer (CRC) treatment. In this study, a "three-level nanoparticle rocket" strategy is developed by engineering CuO, a multifunctional Cu-based nanoenzyme that is photothermal and has electron transfer properties and antioxidant efficiency. CuO effectively remodels the inflammatory environment by scavenging reactive oxygen species, thereby overcoming the traditional limitations of PTT.
View Article and Find Full Text PDFOecologia
January 2025
College of Grassland, Resources and Environment, Inner Mongolia Agricultural University, 29 Ordos Rd., Hohhot, 010011, China.
Although numerous studies have shown that grazing gives rise to community succession from the communities or even species perspective, there is a lack of discussion about how grazing drives community assembly based on plant functional traits in a long-term experiment. We find different grazing intensities lead to temporal effects on trait-mediated multidimensional community assembly processes, including community-weighted trait mean (CWM), trait filtering, and trait distribution (divergence/convergence). CWM, trait filtering, and trait distribution of different traits transformed over the 16-year grazing experiment.
View Article and Find Full Text PDFJ Neurol
January 2025
John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle-upon-Tyne, UK.
PROPEL (ATB200-03; NCT03729362) compared the efficacy and safety of cipaglucosidase alfa plus miglustat (cipa + mig), a two-component therapy for late-onset Pompe disease (LOPD), versus alglucosidase alfa plus placebo (alg + pbo). The primary endpoint was change in 6-min walk distance (6MWD) from baseline to week 52. During PROPEL, COVID-19 interrupted some planned study visits and assessment windows, leading to delayed visits, make-up assessments for patients who missed ≥ 3 successive infusions before planned assessments at weeks 38 and 52, and some advanced visits (end-of-study/early-termination visits).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!