Conjugate eye deviation seen on clinical examination helps to localize pathology in acute ischemic stroke. Eye deviation can also be assessed on a CT head scan. The authors found that CT eye deviation reliably lateralizes to the ischemic hemisphere (positive predictive value 93%) without reference to clinical examination. In an era of thrombolysis and rapid decision making in acute ischemic stroke, eye deviation on CT can help quickly direct attention to the affected hemisphere.
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http://dx.doi.org/10.1212/01.wnl.0000042086.98735.75 | DOI Listing |
J Family Med Prim Care
December 2024
Department of Ophthalmology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.
Purpose: To determine the clinical pattern and burden of strabismus in a teaching institute of Northeast (NE) India.
Methods: In this hospital-based, cross-sectional study, detailed clinical evaluation of patients with manifest strabismus was carried out for a period of one and half years.
Results: Out of the 7222 new outpatient department attendances, a total of 110 new patients with manifest strabismus were found, with a hospital-based burden of 1.
Background: Clinical rating scales and neuropsychological tests are commonly used for assessing sign and disease severity, yet lack detail in the early stages Alzheimer's Disease (AD). Existing evaluation methods can be subjective, nonlinear, expensive, or reliant on anecdotal evidence making objective and consistent characterization and phenotyping of AD difficult. Multimodal analysis of patient behavior, rather than scoring of patient-generated output which can be skewed by compensation strategies, presents a unique opportunity to objectively quantify AD related changes.
View Article and Find Full Text PDFBackground: Sleep's crucial role in maintaining brain health is increasingly recognized, particularly due to the rising prevalence of neurodegenerative diseases. It not only supports cognitive function but also aids in clearing brain metabolic waste through cerebrospinal fluid (CSF) dynamics. During sleep, especially in the non-rapid eye movement (NREM) phase, CSF flow increases, essential for removing neurotoxic substances like amyloid-beta proteins.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Background: Recent studies have identified visual impairment as a potentially modifiable dementia risk factor. However, the underlying mechanism linking visual impairment and cognitive decline is still not fully understood. Additionally, there has been a dearth of research focusing on Latinos.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Clinical rating scales and neuropsychological tests are commonly used for assessing sign and disease severity, yet lack detail in the early stages Alzheimer's Disease (AD). Existing evaluation methods can be subjective, nonlinear, expensive, or reliant on anecdotal evidence making objective and consistent characterization and phenotyping of AD difficult. Multimodal analysis of patient behavior, rather than scoring of patient-generated output which can be skewed by compensation strategies, presents a unique opportunity to objectively quantify AD related changes.
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