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Ischaemic Meckel's Diverticulum, Mesodiverticular Band, and Small Bowel Volvulus With Closed Loop Obstruction: A Laparoscopic Approach and Literature Review.
Cureus
January 2025
Colorectal Surgery, St Mary's Hospital, Isle of Wight NHS Trust, Newport, GBR.
Meckel's diverticulum (MD) is the most common congenital abnormality of the gastrointestinal tract. It usually lies on the antimesenteric side of the ileum, about 60 cm from the ileocecal valve. Histologically, it is a true diverticulum comprising all four layers of the intestinal tract.
View Article and Find Full Text PDFExperience, Outcomes, and Insights on Endoscopic Colonic Polyp Excision: A Retrospective Cohort Study.
Cureus
December 2024
General Surgery, Maidstone and Tunbridge Wells NHS Trust, Maidstone, GBR.
Introduction Colorectal cancer (CRC) continues to pose a major public health challenge, ranking among the most common malignancies globally and being a leading cause of cancer-related mortality. Most CRCs originate from adenomatous polyps, underscoring the importance of detecting and removing these precancerous growths as a key preventive measure against CRC. In particular, large colonic polyps (≥10 mm) warrant special attention due to their increased risk of progressing to malignancy compared to smaller polyps.
View Article and Find Full Text PDFGreen chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer.
SLAS Discov
January 2025
Faculty of Medicine, Galala University, New Galala City 43511, Suez, Egypt.
Brain metastasis (BM) from colon cancer is associated with a poor prognosis and restricted treatment alternatives, largely due to issues related to blood-brain barrier (BBB) permeability and the negative effects of standard chemotherapy. Nanotechnology improves treatment efficacy by enabling targeted and controlled drug delivery. This review article evaluates the potential of nanotechnology-based therapies for treating colon cancer BM, emphasizing their capacity to cross the BBB, diminish metastatic growth, and enhance overall survival rates.
View Article and Find Full Text PDFClaudin 18.2 Expression in 1,404 Digestive Tract Adenocarcinomas including 1,175 Colorectal Carcinomas: Distinct Colorectal Carcinoma Subtypes are Claudin 18.2 Positive.
Mod Pathol
January 2025
Department of Pathology, University of Pittsburgh Medical Center and the University of Pittsburgh, Pittsburgh, PA. Electronic address:
Claudin 18.2 (CLDN18.2) immunohistochemical expression can be used to select patients with gastric/gastroesophageal junction adenocarcinomas for zolbetuximab (IMAB362) therapy, a monoclonal antibody targeting CLDN18.
View Article and Find Full Text PDFInCoLoTransNet: An Involution-Convolution and Locality Attention-Aware Transformer for Precise Colorectal Polyp Segmentation in GI Images.
J Imaging Inform Med
January 2025
Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat, 10000, Morocco.
Gastrointestinal (GI) disease examination presents significant challenges to doctors due to the intricate structure of the human digestive system. Colonoscopy and wireless capsule endoscopy are the most commonly used tools for GI examination. However, the large amount of data generated by these technologies requires the expertise and intervention of doctors for disease identification, making manual analysis a very time-consuming task.
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