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Multi-modal prediction of extracorporeal support-a resource intensive therapy, utilizing a large national database.
JAMIA Open
February 2025
Artificial Intelligence (AI) for Health Institute (AIHealth), Washington University in St Louis, St Louis, MO 63130, United States.
Objective: Extracorporeal membrane oxygenation (ECMO) is among the most resource-intensive therapies in critical care. The COVID-19 pandemic highlighted the lack of ECMO resource allocation tools. We aimed to develop a continuous ECMO risk prediction model to enhance patient triage and resource allocation.
View Article and Find Full Text PDFL-Arginine-Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis.
Small
January 2025
Department of Chemistry, Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, P. R. China.
Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells and disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability in the gut and lack of targeting, hindering precise intervention at the lesion site.
View Article and Find Full Text PDFBioremediation of catecholic pollutants with novel oxygen-insensitive catechol 2,3-dioxygenase and its potential in biomonitoring of catechol in wastewater.
Environ Pollut
January 2025
MTCC-Microbial Type Culture Collection & Gene Bank, CSIR-Institute of Microbial Technology, Chandigarh-160036, India. Electronic address:
The oxygenases are essential in the bioremediation of xenobiotic pollutants. To overcome cultivability constraints, this study aims to identify new potential extradiol dioxygenases using the functional metagenomics approach. RW1-4CC, a novel catechol 2,3-dioxygenase, was isolated using functional metagenomics approach, expressed in a heterologous system, and characterized thoroughly using state-of-the-art techniques.
View Article and Find Full Text PDFLung protective ventilation guided by driving pressure improves pulmonary outcomes in heart transplantation.
Sci Rep
January 2025
Department of Cardiovascular Surgery , Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fujian, 350001, Fuzhou, China.
This study aimed to investigate whether driving pressure-guided ventilation can reduce postoperative pulmonary complications in patients who have undergone heart transplantation. Patients who underwent orthotopic heart transplantation were divided into two groups according to the perioperative ventilation strategy: (1) conventional lung-protective ventilation (group C) and (2) driving pressure-guided ventilation (group D). The primary outcome was the occurrence of postoperative pulmonary complications within 30 days of surgery.
View Article and Find Full Text PDFGenerative adversarial network integrated with metabolomics identifies potential biomarkers related to quality changes of atemoya (Annona cherimola × Annona squamosa) stored at 10 and 25 °C.
Food Chem
December 2024
Department of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. Electronic address:
Atemoya fruit deteriorates rapidly during post-harvest storage. A complete understanding of the metabolic mechanisms underlying this process is crucial for developing effective preservation strategies. Metabolomic approaches combined with machine learning offer new opportunities to identify quality-related biomarkers.
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