We report a case of a 52-year-old woman with a palpable recurrent metastasis of a neuroendocrine carcinoma to the upper outer quadrant of the right breast. For the treatment of this lesion, MR-guided laser-induced thermotherapy was performed with a cooled power laser system (Nd:YAG-Laser). An open 0.2-T MR unit was used for the monitoring of the laser energy delivery to the breast; thus, a thermosensitive fast low-angle shot 2D sequence for MR thermometry was used, so the ablation of the tumor and the increase of laser-induced necrosis could be interactively visualized with the repetitive use of this sequence. The postinterventional MR control exams 1 day and 4 months after laser-induced thermotherapy at the 1.5-T MR unit (Magnetom Symphony Quantum, Siemens, Erlangen, Germany) verified the complete ablation of the tumor without any signs of residual or relapsing tumor.
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http://dx.doi.org/10.1007/s00330-002-1602-0 | DOI Listing |
Comput Biol Med
January 2025
University of Bordeaux, CNRS, CRMSB, UMR 5536, IHU Liryc, Bordeaux, France.
Background: Clinical Laser-Induced Thermotherapy (LITT) currently lacks precise control of tissue temperature increase during the procedure. This study presents a new method to automatically regulate the maximum temperature increase in vivo at different positions by adjusting LITT power delivered by multiple laser probes using real-time volumetric MR-thermometry.
Methods: The regulation algorithm was evaluated in vivo on a pig leg muscle.
Nanoscale
October 2024
HiLASE Centre, FZU - Institute of Physics of the Czech Academy of Sciences, Za Radnicí 828, 25241 Dolní Břežany, Czech Republic.
Although non-toxic nanoscale materials are widely employed for different healthcare applications, their performance is still considerably limited. In this paper, various approaches using the environmentally friendly ultrafast laser processing were employed to remodel IV group semiconductor nanostructures and synthesize highly-stable (-potential is up to -47 mV) colloidal solutions of plasmonic (525 nm) nanocomposites with a strong size-dependent chemical content. All nanocomposites exhibited a remarkable lamp-excited multi-band blue emission centred at around 420 nm that is considerably (∼10-fold for Au-SiC) stronger than from nanocomposites prepared by the laser co-fragmentation technique.
View Article and Find Full Text PDFCureus
July 2024
Department of Physics, St. Peter's College, Kolenchery, IND.
This bibliometric study analyzes the evolving field of thermotherapy, a medical treatment that utilizes heat to treat various conditions, including cancer, by applying controlled temperatures to targeted tissues. Utilizing bibliographic data from the core collection of Web of Science and analysis software Biblioshiny and VOSviewer, we analyzed several key metrics to gain insights into the development and trends in thermotherapy research. The annual scientific production revealed a significant increase in publications over the past two decades, reflecting growing interest in this field.
View Article and Find Full Text PDFACS Appl Mater Interfaces
July 2024
School of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu, China.
Alzheimer's disease (AD) has a complex etiology and diverse pathological processes. The therapeutic effect of single-target drugs is limited, so simultaneous intervention of multiple targets is gradually becoming a new research trend. Critical stages in AD progression involve amyloid-β (Aβ) self-aggregation, metal-ion-triggered fibril formation, and elevated reactive oxygen species (ROS).
View Article and Find Full Text PDFDalton Trans
July 2024
Department of Chemistry, Faculty of Natural Science, Sepuluh Nopember Institute of Technology, Keputih, Sukolilo, Surabaya 60111, Indonesia.
The design of multimodal cancer therapy was focused on reaching an efficient process and minimizing harmful effects on patients. In the present study, the Au-MnO nanostructures have been successfully constructed and produced as novel multipurpose photosensitive agents simultaneously for photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). The prepared AuNPs were conjugated with MnO NPs by its participation in the thermal decomposition process of KMnO confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy (FT-IR).
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