Diphenoxylate was administered to mice at the dose of 5 mg/kg BW for the development of peristaltic inhibition model for formulating the examination procedure of health foods. An ink solution containing 5% charcoal was then administered 30 minutes later. The length of ink progradation of the small intestine of mice was calculated 25 minutes after the administration of ink. The results in this model was stable and reliable, and it was recommended to use this model to verify the function of health foods.
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J Physiol
December 2024
Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
The peristaltic reflex has been a central concept in gastrointestinal motility; however, evidence was published recently suggesting that post-stimulus responses that follow inhibitory neural responses provide the main propulsive force in colonic motility. This new concept was based on experiments on proximal colon where enteric inhibitory neural inputs are mainly nitrergic. However, the nature of inhibitory neural inputs changes from proximal to distal colon where purinergic inhibitory regulation dominates.
View Article and Find Full Text PDFJ Neurogastroenterol Motil
October 2024
Dysphagia Research Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Biomaterials
January 2025
Chemical Biology Unit, Institute of Nano Science and Technology, Sector 81, Knowledge City, Sahibzada Ajit Singh Nagar, Mohali, Punjab, 140306, India. Electronic address:
Directly administering medication to inflamed intestinal sites for treating ulcerative colitis (UC), poses significant challenges like retention time, absorption variability, side effects, drug stability, and non-specific delivery. Recent advancements in therapy to treat colitis aim to improve local drug availability that is enema therapy at the site of inflammation, thereby reducing systemic adverse effects. Nevertheless, a key limitation lies in enemas' inability to sustain medication in the colon due to rapid peristaltic movement, diarrhea, and poor local adherence.
View Article and Find Full Text PDFBMC Vet Res
June 2024
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Background: Actinobacillus pleuropneumoniae is a serious pathogen in pigs. The abundant application of antibiotics has resulted in the gradual emergence of drugresistant bacteria, which has seriously affected treatment of disease. To aid measures to prevent the emergence and spread of drug-resistant bacteria, herein, the kill rate and mutant selection window (MSW) of danofloxacin (DAN) against A.
View Article and Find Full Text PDFGastro Hep Adv
October 2023
Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, California.
Esophageal peristalsis involves a sequential process of initial inhibition (relaxation) and excitation (contraction), both occurring from the cranial to caudal direction. The bolus induces luminal distension during initial inhibition (receptive relaxation) that facilitates smooth propulsion by contraction travelling behind the bolus. Luminal distension during peristalsis in normal subjects exhibits unique characteristics that are influenced by bolus volume, bolus viscosity, and posture, suggesting a potential interaction between distension and contraction.
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