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Proteomics of blood extracellular vesicles in inflammatory respiratory diseases for biomarker discovery and new insights into pathophysiology.
Inflamm Regen
September 2024
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Background: Inflammatory respiratory diseases, such as interstitial lung disease (ILD), bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), and respiratory infections, remain significant global health concerns owing to their chronic and severe nature. Emerging as a valuable resource, blood extracellular vesicles (EVs) offer insights into disease pathophysiology and biomarker discovery in these conditions.
Main Body: This review explores the advancements in blood EV proteomics for inflammatory respiratory diseases, highlighting their potential as non-invasive diagnostic and prognostic tools.
Allergo-immunopathology mechanism of thymol-inhibiting airway remodeling in asthmatic mice by regulating TGF-β/Smad3 pathway.
Allergol Immunopathol (Madr)
September 2024
Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China;
Allergic asthma is an important public health problem and is a complicated respiratory sickness that is characterized by bronchial inflammation, bronchoconstriction, and breathlessness. Asthma is orchestrated by type 2 immune response and remodeling is one of the important outputted problem in chronic asthma. Thymol is a naturally occurring monocyclic phenolic, it has a series of biological properties, and its immunomodulatory and anti-remodeling effects on allergic asthma were evaluated.
View Article and Find Full Text PDFCoinhibitory Molecule VISTA Play an Important Negative Regulatory Role in the Immunopathology of Bronchial Asthma.
J Asthma Allergy
September 2024
Respiratory Department, Children's Hospital of Soochow University, Suzhou, People's Republic of China.
Objective: To investigate the significance of VISTA in bronchial asthma and its impact on the disease.
Methods: Human peripheral blood of asthma children was gathered. The expression concentrations of VISTA, IL-4, IL-6, CD25, CD40L, and PD-L2 in peripheral blood plasma were detected by ELISA.
Can probiotics be used in the prevention and treatment of bronchial asthma?
Pharmacol Rep
August 2024
Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Żeligowskiego 7/9, Łódź, 90-752, Poland.
Asthma is a lifelong condition with varying degrees of severity and susceptibility to symptom control. Recent studies have examined the effects of individual genus, species, and strains of probiotic microorganisms on the course of asthma. The present review aims to provide an overview of current knowledge on the use of probiotic microorganisms, mainly bacteria of the genus Lactobacillus and Bifidobacterium, in asthma prevention and treatment.
View Article and Find Full Text PDFHazard assessment of hexagonal boron nitride and hexagonal boron nitride reinforced thermoplastic polyurethane composites using human skin and lung cells.
J Hazard Mater
July 2024
Department of Life Sciences, University of Trieste, Trieste, Italy. Electronic address:
Article Synopsis
- Hexagonal boron nitride (hBN) is a promising two-dimensional material with unique properties, but there are potential risks for workers due to exposure through inhalation and skin contact.
- This study aimed to evaluate the impacts of composites made from thermoplastic polyurethane (TPU) and hBN on skin and lung cells by examining their cellular uptake, cytotoxicity, and inflammation over both short (24 hours) and long-term (4 weeks) exposure periods.
- Overall, despite some cellular uptake of the composites, the research found no significant changes in cell health or protein expression in the exposed cells, with only a few inflammatory proteins identified, suggesting low hazard levels for workers handling these materials.
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