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Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update.
Cancers (Basel)
September 2024
Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Article Synopsis
- Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare fat tumor that usually appears in the skin layer of middle-aged adults' limbs, potentially returning after incomplete removal but not spreading to distant areas.
- Histologically resembling spindle cell/pleomorphic lipoma, ASCPLT shows a mix of abnormal cells, including atypical spindle cells and multinucleated giant cells, and can sometimes undergo a change to a more aggressive form, although its significance is still unclear.
- The primary treatment is complete surgical removal, and the review covers the tumor's clinical features, pathology, and ongoing discussions about differentiating it from similar tumors.
Lipid-Laden Floret-Like Multinucleated Giant Cells: A Novel Histopathologic Observation in Rhinophyma.
Am J Dermatopathol
November 2024
Department of Dermatopathology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom ; and.
Rhinophyma is the advanced stage of rosacea and manifests clinically with disfigurement of the nose. The histopathology has been classified into classical and severe types. We studied the clinicopathological characteristics of 8 cases with the diagnosis of rhinophyma.
View Article and Find Full Text PDFSpindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review.
Cancer Diagn Progn
May 2023
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. The lesion typically presents as a relatively small (<5 cm), mobile, slow-growing, painless mass.
View Article and Find Full Text PDFTransoral robotic resection of unusual spindle cell/pleomorphic lipoma of the larynx.
J Minim Access Surg
January 2021
Department of Otorhinolaryngology and Head and Neck, Marly Clinic, Bogotá DC; Department of Otorhinolaryngology, Section of Laryngology, Children's University Hospital of San José, University Foundation of Health Sciences, Bogotá, Colombia.
Spindle cell/pleomorphic lipoma (SC/PL) is a subcutaneous mass usually localised on nape, shoulder or upper back. It is a benign lipogenic tumour composed of primitive CD34-positive spindle cells, floret-like multinucleated giant cells and mature adipocytes. Complete surgical excision is the optimal treatment.
View Article and Find Full Text PDFFat-free pleomorphic lipoma of the buccal mucosa: An immunohistochemical study and literature review.
Oral Oncol
June 2021
Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research, Tiradentes University (UNIT), Aracaju, SE, Brazil.
Pleomorphic lipomas are extremely rare in the oral cavity. Due to the significant overlap of morphological findings with several benign and malignant soft tissue tumors, especially in the absence of adipocytes, the diagnosis is challenging. We reported the clinicopathological and immunohistochemical features of an uncommon case of a fat-free variant of pleomorphic lipoma in a 48-year-old female presenting clinically as a painless nodule on the buccal mucosa.
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