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Circulating miR-29c, miR-195, and miR-486 Are Objective Indicators to Determine the Moderate Intensity of Resistance Exercise.
Cureus
December 2024
Life and Medical Sciences Area, Health Sciences Discipline, Kobe University, Kobe, JPN.
Background and objective Moderate exercise is important for health; however, there are variations among individuals in terms of characterizing moderate intensity and it is difficult to identify. In light of this, the purpose of this study was to identify new objective indicators to determine effective exercise intensity. Methods This study involved both human and animal experiments.
View Article and Find Full Text PDFDEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure.
Front Cardiovasc Med
January 2025
Department of Nephrology, Nanchong Central Hospital Affiliated to North Sichuan Medical College, Nanchong, China.
Introduction: Heart failure (HF) has a very high prevalence in patients with maintenance hemodialysis (MHD). However, there is still a lack of effective and reliable HF diagnostic markers and therapeutic targets for patients with MHD.
Methods: In this study, we analyzed transcriptome profiles of 30 patients with MHD by high-throughput sequencing.
Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy.
J Nanobiotechnology
January 2025
Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.
Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF therapies due to resistance and limited efficacy. Recent studies have highlighted the roles of noncoding RNAs in various biological processes, paving the way for RNA-based therapeutics.
View Article and Find Full Text PDFLong noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism.
Sci Rep
January 2025
Department of Spinal Surgery, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Central Guangzhou, Guangdong510280, Guangzhou, Guangdong510280, China.
Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. However, its function and molecular mechanism in OS remain largely unknown.
View Article and Find Full Text PDFMechanism of TGIF1 on glycolipid metabolism disorders in mice with type 2 diabetes.
BMJ Open Diabetes Res Care
January 2025
The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong, China
Introduction: Type 2 diabetes (T2D) is a chronic condition characterized by high levels of blood glucose resulting from the inefficiency of insulin. This study aims to explore the mechanism of TGFB-induced factor homeobox 1 (TGIF1) in the glycolipid metabolism of mice with T2D.
Research Design And Methods: Mice with T2D were induced by high-fat diet and low-dose streptozotocin (STZ) injection.
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