Most medical school alcohol, tobacco and other drug (ATOD) curricula emphasize the diagnosis and treatment of alcohol abuse and dependence, even though a significant amount of alcohol-related morbidity and mortality is associated with the hazardous use of alcohol. An increased emphasis on screening for hazardous drinking and the use of early intervention has been shown to be effective in reducing heavy drinking in the primary care setting. This paper describes a family medicine clerkship seminar on clinical preventive medicine that focuses on tobacco and alcohol use. Results indicate that students learn that brief intervention counseling can influence patient behavior and plan to continue to use it in future patient encounters. However, the low number of students electing to intervene in hazardous drinking suggests that more curricular time is needed to overcome student resistance to addressing the alcohol use patterns of their patients.
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http://dx.doi.org/10.1080/08897079809511368 | DOI Listing |
Aging Cell
January 2025
MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Metabolomics and epigenomics have been used to develop 'ageing clocks' that assess biological age and identify 'accelerated ageing'. While metabolites are subject to short-term variation, DNA methylation (DNAm) may capture longer-term metabolic changes. We aimed to develop a hybrid DNAm-metabolic clock using DNAm as metabolite surrogates ('DNAm-metabolites') for age prediction.
View Article and Find Full Text PDFZhonghua Liu Xing Bing Xue Za Zhi
January 2025
Institute of Population Research/Chinese Center for Population Health and Development, Peking University, Beijing100871, China.
To assess the association between possible sarcopenia and the risk for frailty in middle-aged and elderly adults in China. A prospective cohort study design was used in this study. Data were from the China Health and Retirement Longitudinal Study during 2011-2018 and the baseline data in 2011, the follow up was conducted in 2013, 2015 and 2018, respectively.
View Article and Find Full Text PDFEnviron Res
January 2025
School of Environmental Science & Engineering, Tianjin University, Tianjin 300350, China.
Sudden biological contamination in Drinking Water Distribution System (DWDS) significantly threatens the safety of drinking water, with E. coli invasions being particularly hazardous to human health. Traditional disinfection methods (i.
View Article and Find Full Text PDFRegul Toxicol Pharmacol
January 2025
AstraZeneca, Global Sustainability, The Netherlands.
The EU Commission proposal for a new EU pharmaceutical legislation considers PBT (persistence-bioaccumulation-toxicity) and PMT (persistence-mobility-toxicity) criteria for pharmaceuticals. Under current environmental risk assessment guidance, a PBT assessment is required regardless of the predicted environmental concentrations. However, consumption volumes of pharmaceuticals are contingent on marketing approval by EMA and are therefore predictable and their toxicological potency is established prior to any regulatory approval.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. Electronic address:
Synergistic activation of persulfate by photothermal and solid catalysts is an effective method for degrading organic pollutants. However, the batch reaction mode not only fails to fully utilize photothermal, but also makes it hard to separate the solid catalysts from the reaction solution. In this work, a shallow continuous flow way of effluent was set up for synergistic activation of peroxydisulfate (PDS) by photothermal and FeS-loaded air-laid cloth (FeS-ALC).
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