Background: Several modifications of the TNM system have been reported as better prognostic tools than the original classification in head and neck cancer, but none of these modifications has been tested in a large series of tonsillar carcinomas. These studies did not examine host and treatment factors as predictors in addition to TNM.
Methods: Three hundred and ten consecutively untreated patients with squamous cell carcinoma of the tonsillar region admitted to the Norwegian Radium Hospital and/or the National Hospital between 1960 and 1996 were included.
Results: The five reported TN-based stage modifications were all highly significant predictors of survival. Four clinical variables indicating shorter disease-specific survival were identified: age > 60, male gender, total radiation dose < 70 Gy, and duration of radiotherapy > 50 days.
Conclusions: Earlier reported TNM-based stage modifications are all very useful predictors of survival in tonsillar carcinomas. In addition, age, gender, total radiation dose, and duration of radiotherapy were important prognostic factors. We propose that both host and treatment factors should be tested carefully when building new prognostic indices in tonsillar carcinomas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.10175 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comments on "Tonsillar tuberculosis mimicking tonsillar carcinoma: A case report" based on ChatGPT approach.
Int J Surg Case Rep
January 2025
Department of Internal Medicine, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. Electronic address:
The Effectiveness of Tonsillectomy in the Diagnostic Workup of Squamous Cell Carcinoma Unknown Primary in the Head and Neck Based on p16 Immunohistochemistry.
Medicina (Kaunas)
November 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Medical Faculty, Comenius University Bratislava, 851 07 Bratislava, Slovakia.
: Despite the distinct entity of both p16-positive and p16-negative squamous cell carcinoma unknown primary in the head and neck (HNSCCUP), the diagnostic workup did not differ. The aim of the study was to determine the effectiveness of palatine tonsillectomy in the identification of primary tumours in two groups of p16-positive and p16-negative HNSCCUP. : Patients with HNSCCUP managed in two tertiary care referral centres from 1 January 2014 to 31 December 2020 were analysed retrospectively.
View Article and Find Full Text PDFExternal Carotid Artery Ligation Versus Selective Artery Ligation in Transoral Surgery for Oropharyngeal Cancer.
Otolaryngol Head Neck Surg
December 2024
ENT Specialty Care, Dallas, Texas, USA.
Objective: Prophylactic ligation of the external carotid artery (ECA) during oropharyngeal squamous cell carcinoma (OPSCC) resection is known to reduce severe postoperative oropharyngeal bleeding events, however, there is limited research on whether bleed rates vary between selective ligation of individual vessels or total ligation of the ECA. This study assesses outcomes related to total versus selective ligation of the ECA in patients who underwent transoral resection for OPSCC of the base of tongue or palatine tonsils.
Study Design: Retrospective review.
Adenoid cystic carcinoma of palatine tonsil: A case report.
Sci Prog
December 2024
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.
In head and neck, adenoid cystic carcinoma (ACC) is a rare malignant tumor. ACC mainly generated from minor salivary glands, especially in the palate. We report an extremely rare case of ACC generating in the left palatine tonsil.
View Article and Find Full Text PDFInterleukin-6 promotes the epithelial mesenchymal transition in canine tonsillar squamous cell carcinoma cells.
Res Vet Sci
December 2024
Laboratory of Veterinary Radiology, School of Veterinary Science, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka 598-8531, Japan.
Canine oral squamous cell carcinoma (CoSCC) is often associated with suppurative inflammation. Metastasis of malignant tumors is one of the signs of major interest in oncology because it speaks of disease progression, where the involvement of interleukin-6 (IL-6) in cancer progression is so far unknown. Therefore, the aim of this study was the determination of the role of IL-6 in metastasis in CoSCC cells model through expression analysis of mRNA and protein using real-time PCR and western blotting and assessment of cell migration and invasion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!