Although working with human pathogens and zoonotic agents has always carried a certain degree of danger, current events have resulted in an increased focus on the subject, including new regulations. The authors discuss a number of risk assessment and management activities that animal research facilities should use to evaluate strengthen their current programs.

Download full-text PDF

Source
http://dx.doi.org/10.1038/laban0103-32DOI Listing

Publication Analysis

Top Keywords

animal facilities
8
biosecurity animal
4
facilities associated
4
associated laboratories
4
laboratories working
4
working human
4
human pathogens
4
pathogens zoonotic
4
zoonotic agents
4
agents carried
4

Similar Publications

For over a century African swine fever (ASF) has been causing outbreaks leading to devastating losses for the swine industry. The current pandemic of ASF has shown no signs of stopping and continues to spread causing outbreaks in additional countries. Currently control relies mostly on culling infected farms, and strict biosecurity procedures.

View Article and Find Full Text PDF

Accumulating evidence indicates that cellular senescence is closely associated with osteoarthritis. However, there is limited research on the mechanisms underlying fibroblast-like synoviocyte senescence and its impact on osteoarthritis progression. Here, we elucidate a positive correlation between fibroblast-like synoviocyte senescence and osteoarthritis progression and reveal that GATD3A deficiency induces fibroblast-like synoviocyte senescence.

View Article and Find Full Text PDF

Circuit-based biomarkers distinguishing the gradual progression of Lewy pathology across synucleinopathies remain unknown. Here, we show that seeding of α-synuclein preformed fibrils in mouse dorsal striatum and motor cortex leads to distinct prodromal-phase cortical dysfunction across months. Our findings reveal that while both seeding sites had increased cortical pathology and hyperexcitability, distinct differences in electrophysiological and cellular ensemble patterns were crucial in distinguishing pathology spread between the two seeding sites.

View Article and Find Full Text PDF

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an overactive immune response, particularly involving excessive production of type I interferons. This overproduction is driven by the phosphorylation of IRF7, a crucial factor in interferon gene activation. Current treatments for SLE are often not very effective and can have serious side effects.

View Article and Find Full Text PDF

Recent progress in camel research.

Open Vet J

November 2024

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Background: Camelids play an important role in the preservation of ecosystems, biodiversity, food security, economic growth, adaptation to climate change, and cultural and social aspects. Therefore, the United Nations has named 2024 the International Year of Camelids (IYC).

Aim: This study aimed to assess the recent progress in camel research and its citation effect as shown in the Scopus database in the IYC.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!