AI Article Synopsis
- The EMI domain was named after proteins in the EMILIN family and has been found in various proteins across different animal species.
- The NEU1/NG3 proteins in mammals and CED-1 in C. elegans act as transmembrane receptors involved in cell corpse engulfment.
- Research suggests that the EMI domain may function as a protein-protein interaction module, leading to the identification of related proteins in mammals and insects that had not been previously discovered.
Article Abstract
The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.
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| http://dx.doi.org/10.1016/s0006-291x(02)02904-2 | DOI Listing |
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