Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Cancer Detect Prev
Laboratory of Oncology, Istituto G. Gaslini, L go Gaslini 5, Genova 16148, Italy.
Published: June 2003
In this study, a new syngeneic murine neuroblastoma (NB) model resembling stage 3 NB with thoracic localization has been set up by intramediastinal injection of tumor cells. Two NB cell lines, the murine Neuro2a, and the hybrid NXS2, have been injected in A/J mice. In vivo tumor growth and dissemination have been assessed by macroscopic and microscopic histological analysis performed at different times post injection. Tumor cell localization and growth patterns were compared to those obtained by i.v. and r.p. injections. The results indicated that in the thoracic model both tumor cell lines grow rapidly as huge tumor masses but do not metastatize to distant organs. This new model may be relevant for testing the efficacy of novel immunotherapeutic strategies for poor prognosis NB patients with localized disease.
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http://dx.doi.org/10.1016/s0361-090x(02)00129-0 | DOI Listing |
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