"Plus-disease" is a particular grave form of retinopathy of premature babies found in 7% of extremely premature and somatically loaded children. The following criteria are indicative of "plus-disease": location of pathological changes in the central zone of eye fundus (zone 1-2), marked vascular activity and hemorrhages in the center and on the periphery of the retina, pupil regidity, iris vasodilatation and fulminant (3 days-3 weeks) progression of the process from initial signs up to signs of extraretinal growth or exudative amotio retinae without forming premature stages typical for retinopathy (torus lines). Upon revealing the first signs of "plus-disease" ophthalmological examinations should be carried out with the interval of 2-3 days. To increase efficiency of preventive treatment it is recommended to use the combined procedure of cryo- and laser coagulation of avascular zones and a zone of vascular amostosis in appearance of extraretinal vascular growth, which makes it possible to arrest disease progression in 75% of cases.
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