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A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.
Front Oncol
December 2024
Oncoclinicas (OC) Medicina de Precisão (OCPM), São Paulo, Brazil.
Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.
View Article and Find Full Text PDFThe role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications.
J Mol Med (Berl)
January 2025
Department of Genetics and Bioengineering, Alanya Alaaddin Keykubat University, Antalya, 07425, Turkey.
The tumor microenvironment, which is the tailored physiological milieu of heterogeneous cancer cell populations surrounded by stromal and immune cells as well as extracellular matrix components, is a leading modulator of critical cancer hallmarks and one of the most significant prognostic indicators in breast cancer. In the last few decades, with the discovery of the interactions of ncRNAs with diverse cellular molecules, considerable emphasis has been devoted to understanding their direct and indirect roles in specific functions in breast cancer. Collectively, all of these have revealed that the competitive action of protein-coding RNAs and ncRNAs such as circRNAs and lncRNAs, which have a shared affinity for miRNAs, play a vital role in the molecular regulation of breast cancer.
View Article and Find Full Text PDFA molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity.
Proc Natl Acad Sci U S A
October 2024
Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Cancers develop resistance to inhibitors of oncogenes mainly due to target-centric mechanisms such as mutations and splicing. While inhibitors or antagonists force targets to unnatural conformation contributing to protein instability and resistance, activating tumor suppressors may maintain the protein in an agonistic conformation to elicit sustainable growth inhibition. Due to the lack of tumor suppressor agonists, this hypothesis and the mechanisms underlying resistance are not understood.
View Article and Find Full Text PDFProgressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.
Nat Commun
June 2024
Westlake Disease Modeling lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Article Synopsis
- Cancer rates increase significantly with age, but the exact reasons for this link are still not fully understood. This research focuses on understanding how aging affects mammary cells in female mice at a molecular level.
- The study identifies two phases of the aging process: an early senescence phase followed by a later phase characterized by increased cancer-related pathways, driven by a stem cell factor called Bcl11b. Losing Bcl11b speeds up aging and raises the risk of tumors from carcinogenic substances.
- Researchers discovered a drug, TPCA-1, that can potentially reverse aging effects in mammary cells, reducing the likelihood of age-related cancers, thereby offering insights that could help in managing cancer risk among older populations.
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