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The Expression of the LDLR, LDLRAP1, and PCSK9 Genes has Prognostic Significance in Triple-negative Breast Cancer.
Curr Med Chem
January 2025
Laboratory for Research on Molecular Mechanisms of Longevity, Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Aims: The purpose of this study was to investigate the prognostic significance of cholesterol uptake genes in predicting the survival of breast cancer patients.
Background: Cholesterol plays a crucial role in the homeostasis of tumor cells. It is known that cholesterol levels can influence important parameters of the disease, such as sensitivity to therapy, progression, and metastasis of cancer.
Hormonal Implications of SARS-CoV-2: A Review of Endocrine Disruptions.
Scientifica (Cairo)
January 2025
Department of Natural Sciences, Akhmet Baitursynuly Kostanay Regional University, Kostanay, Kazakhstan.
To improve medical care and rehabilitation algorithms for patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is important to evaluate and summarize the available data on the effect of coronavirus infection (COVID-19) on the endocrine system. The purpose of this review was to study the effect of COVID-19 on the endocrine system. The scientific novelty of this study is the evaluation of the effect of coronavirus infection on the endocrine system and the potential effect of hormones on susceptibility to COVID-19.
View Article and Find Full Text PDFNovel method for detection of Aβ and Iso-D7-Aβ N-terminus-specific B cells and Iso-D7-Aβ-specific antibodies.
Biol Methods Protoc
January 2025
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia.
Alzheimer's disease (AD) is a multifactorial systemic disease that is triggered, at least in part, by the accumulation of β-amyloid (Aβ) peptides in the brain, but it also depends on immune system-mediated regulation. Recent studies suggest that B cells may play a role in AD development and point to the accumulation of clonally expanded B cells in AD patients. However, the specificity of the clonally expanded B cells is unknown, and the contribution of Aβ-specific B cells to AD pathology development is unclear.
View Article and Find Full Text PDFSymbiosis and horizontal gene transfer promote herbivory in the megadiverse leaf beetles.
Curr Biol
January 2025
Department of Insect Symbiosis, Max Planck Institute for Chemical Ecology, Hans-Knoell-Str. 8, 07745 Jena, Germany. Electronic address:
Beetles that feed on the nutritionally depauperate and recalcitrant tissues provided by the leaves, stems, and roots of living plants comprise one-quarter of herbivorous insect species. Among the key adaptations for herbivory are plant cell wall-degrading enzymes (PCWDEs) that break down the fastidious polymers in the cell wall and grant access to the nutritious cell content. While largely absent from the non-herbivorous ancestors of beetles, such PCWDEs were occasionally acquired via horizontal gene transfer (HGT) or by the uptake of digestive symbionts.
View Article and Find Full Text PDFSubjective trauma perception as a Distinctive predictor of somatization and disability during the 2022 Russian invasion of Ukraine.
J Psychiatr Res
January 2025
School of Social Work, Ariel University, Ariel, Israel. Electronic address:
Objectives: This study examines the association between the Subjective Traumatic Outlook (STO), somatization, and physical and mental aspects of disability during wartime in Ukraine. It highlights the STO's role in emphasizing the perceptual component of trauma as a screening tool, distinguishing somatic symptoms alongside physical and psychological disability.
Method: A national sample of 1895 Ukrainians affected by the Russian invasion completed the International Trauma Questionnaire (ITQ), the Somatic Symptom Scale-8 (SSS-8), the World Health Organization Disability Assessment Schedule (WHODAS), and the STO.
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