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Preclinical model of Mycobacteroides abscessus lung disease by nose-only exposure of mice to bacterial powder aerosol.
Tuberculosis (Edinb)
January 2025
CSIR-Central Drug Research Institute, Lucknow, 226031, UP, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, UP, India. Electronic address:
The limitations of existing mouse models of lung infection with Mycobacteroides abscessus impede drug discovery and development. In contrast to current animal models that introduce NTM intravenously or by intranasal/intra-tracheal instillation or via bronchoscopy-guided insufflation, we developed a dry powder inhalation (DPI) of M. abscessus ATCC 19977 that generated paucibacillary lung infection and histopathology in immunocompetent mice.
View Article and Find Full Text PDFPhenotypic Plasticity During Organofluorine Degradation Revealed by Adaptive Evolution.
Microb Biotechnol
December 2024
Department of Biochemistry, Molecular Biology and Biophysics and Biotechnology Institute, University of Minnesota, Twin Cities, USA.
A major factor limiting the biodegradation of organofluorine compounds has been highlighted as fluoride anion toxicity produced by defluorinating enzymes. Here, two highly active defluorinases with different activities were constitutively expressed in Pseudomonas putida ATCC 12633 to examine adaption to fluoride stress. Each strain was grown on α-fluorophenylacetic acid as the sole carbon source via defluorination to mandelic acid, and each showed immediate fluoride release and delayed growth.
View Article and Find Full Text PDFAntifungal activity of Myrrh gum resin against pathogenic spp.
Ann Agric Environ Med
September 2024
Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Article Synopsis
- - The study investigates the effectiveness of water-based extracts from two varieties of myrrh in inhibiting the growth of various pathogenic yeasts, showcasing the historical significance of medicinal plants in healing.
- - Using diffusion techniques and mass spectrometry, the extracts demonstrated antifungal activity against five yeast strains, with essential oils exhibiting the strongest effects on specific ATCC strains and revealing 12 antimicrobial components.
- - The findings indicate that myrrh extracts possess promising antifungal properties, but additional research is needed to understand their mechanisms of action and assess safety for potential clinical use.
Fabrication and biocompatibility evaluation of hydroxyapatite-polycaprolactone-gelatin composite nanofibers as a bone scaffold.
RSC Adv
August 2024
Institute of Nanoscience and Nanotechnology, Universiti Putra Malaysia UPM Serdang 43400 Selangor Malaysia.
One approach to addressing bone defects involves the field of bone tissue engineering, with scaffolds playing an important role. The properties of the scaffold must be similar to those of natural bone, including pore size, porosity, interconnectivity, mechanical attributes, degradation rate, non-toxicity, non-immunogenicity, and biocompatibility. The primary goals of this study are as follows: first, to evaluate hydroxyapatite (HA)/polycaprolactone (PCL)/gelatin nanofiber scaffolds based on functional groups, fibre diameter, porosity, and degradation rate; second, to investigate the interaction between HA/PCL/gelatin scaffolds and osteoblast cells (specifically, the ATCC 7F2 cell line) using assays, including cell viability and adhesion levels.
View Article and Find Full Text PDFDecoding the TAome and computational insights into parDE toxin-antitoxin systems in Pseudomonas aeruginosa.
Arch Microbiol
July 2024
School of Biotechnology, Gautam Buddha University, Greater Noida, Yamuna Expressway, Greater Noida, 201312, Uttar Pradesh, India.
Toxin-antitoxin (TA) modules are widely found in the genomes of pathogenic bacteria. They regulate vital cellular functions like transcription, translation, and DNA replication, and are therefore essential to the survival of bacteria under stress. With a focus on the type II parDE modules, this study thoroughly examines TAome in Pseudomonas aeruginosa, a bacterium well-known for its adaptability and antibiotic resistance.
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