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REV7: a small but mighty regulator of genome maintenance and cancer development.
Front Oncol
January 2025
Department of Biology, Tufts University, Medford, MA, United States.
REV7, also known as MAD2B, MAD2L2, and FANCV, is a HORMA-domain family protein crucial to multiple genome stability pathways. REV7's canonical role is as a member of polymerase ζ, a specialized translesion synthesis polymerase essential for DNA damage tolerance. REV7 also ensures accurate cell cycle progression and prevents premature mitotic progression by sequestering an anaphase-promoting complex/cyclosome activator.
View Article and Find Full Text PDFUltrafast dynamic contrast-enhanced breast MRI with quantitative perfusion parameters in differentiating breast cancer: a study focusing on triple-negative and HER2 positive breast cancer.
Front Oncol
January 2025
Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: In the realm of breast cancer diagnosis and treatment, accurately discerning molecular subtypes is of paramount importance, especially when aiming to avoid invasive tests. The updated guidelines for diagnosing and treating HER2 positive advanced breast cancer, as presented at the 2021 National Breast Cancer Conference and the Annual Meeting of the Chinese Society of Clinical Oncology, highlight the significance of this approach. A new generation of drug-antibody combinations has emerged, expanding the array of treatment options for HER2 positive advanced breast cancer and significantly improving patient survival rates.
View Article and Find Full Text PDFPositive margins after breast-conserving surgery: is it possible to hang up the scalpel in the era of precision medicine?
Updates Surg
January 2025
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy.
Admitted when Breastfeeding: Impact and Experiences of Hospital Care.
Breastfeed Med
January 2025
Department of Mathematics, Universitat Politècnica de Catalunya, Barcelona, Spain.
This study analyzes the impact and experiences of hospitalization for any reason on breastfeeding women. Cross-sectional online survey (November 2019-March 2020). Adults admitted to a Spanish hospital for at least one night, when actively breastfeeding, were included.
View Article and Find Full Text PDFPatient-Friendly Summary of the ACR Appropriateness Criteria®: Supplemental Breast Cancer Screening Based on Breast Density: 2024 Update.
J Am Coll Radiol
January 2025
New York University Grossman School of Medicine, 160 East 34(th) St, New York, NY 10016. Electronic address:
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