Antibiotic IC101 is a cyclic hexadepsipeptide having a C(15) lipophilic side chain. The side chain was shown to be synthesized in Streptomyces from acetate, propionate, and 3-methylbutyrate derived from leucine. Thus, the terminal isopentyl structure came from leucine and not from the mevalonate pathway.
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| http://dx.doi.org/10.1021/np0202069 | DOI Listing |
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