The analysis of the choice and distribution of the fixed frequencies in the course of audiometry and mechanisms of automatic regulation in the hearing system (HS) gave grounds to suppose that: 1) HS is rather a multichannel system than a single channel, the number of channels being equal to the number of frequency critical acoustic bands (that is 24); 2) not one but 24 mechanisms of threshold hearing adaptation operate in HS, one for each critical hearing band; 3) the number of fixed frequencies at which audiometry is made (125 Hz-8 kHz) should be 21 while now it is 9 and these frequencies should not change by ostave, but must correspond to central frequencies of critical hearing bands this number of frequencies being optimal.
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Gastric Cancer
January 2025
Department of Medical Oncology, Hospital Clinico Universitario, INCLIVA, Biomedical Research Institute, University of Valencia, Avenida Menendez Pelayo nro 4 accesorio, Valencia, Spain.
Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.
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Child Abuse Negl
January 2025
Division of Epidemiology, School of Public Health, University of California, 2121 Berkeley Way West, Berkeley, CA 94720, USA; Division of Biostatistics, School of Public Health, University of California, 2121 Berkeley Way West, Berkeley, CA 94720, USA.
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View Article and Find Full Text PDFPLoS One
January 2025
Kyiv School of Economics, Kyiv, Ukraine.
Cancer Immunol Immunother
January 2025
Departments of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Background: Esophageal cancer (ESC) is an aggressive disease which often presents at an advanced stage. Despite trimodal therapy, 40-50% patients can develop metastatic disease by 18 months. Identification of patients at risk for metastatic spread is challenging with need for improved prognostication.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Interdisciplinary Institute for Neuroscience (UMR 5297), University of Bordeaux, Bordeaux, Gironde, France.
This is a maximal intensity projection of CA1 pyramidal cell transfected with plasmid with the reporter GFP using single cell electroporation technique. In this particular case the organotypic slices were prepared from p5-7 pups in a tissue chopper (McIlwain). And maintained in MEM bases media with added glutamax with a change in 2 alternative dyas at 37°C and 5% CO for 4 days in-vitro (DIV) before electroporating with a glass pipette of 7-10mΩ resistance by applying 4 square pulses of -ve voltage of -2.
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