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Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study.
Pol J Microbiol
December 2024
Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Epidemiological studies and animal models have suggested a possible link between gut microbiota (GM), circulating metabolites, and endometriosis (EMs) pathogenesis. However, whether these associations are causal or merely due to confounding factors remains unclear. We conducted a two-sample and two-step Mendelian randomization (MR) study to elucidate the potential causal relationship between GM and EMs, and the mediating role of circulating metabolites.
View Article and Find Full Text PDFMultiomics of yaks reveals significant contribution of microbiome into host metabolism.
NPJ Biofilms Microbiomes
November 2024
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, 528000, China.
An intensive feeding system might improve the production cycle of yaks. However, how intensive feeding system contributes to yak growth is unclear. Here, multi-omics, including rumen metagenomics, rumen and plasma metabolomics, were performed to classify the regulatory mechanisms of intensive feeding system on yaks.
View Article and Find Full Text PDF: a comprehensive review.
J Oral Microbiol
November 2024
Aix-Marseille Université, Microbes Evolution, Phylogénie et Infection (MEPHI), Marseille, France.
() has predominated human oral microbiota methanogenic archaea as far back as the Palaeolithic era in Neanderthal populations and gained dominance from the 18 century onwards. was initially isolated from dental plaque samples collected from two apparently healthy individuals allowing its first characterization. The culture of is fastidious and has been the subject of several studies to improve its laboratory growth.
View Article and Find Full Text PDFDoes gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease?
BMC Microbiol
October 2024
Department of Translational Medical Science, University of Campania Luigi Vanvitelli, Naples, Italy.
Background: Chronic Kidney Disease (CKD) is characterized by a methionine-related metabolic disorder involving reduced plasma levels of hydrogen sulfide (HS) and increased lanthionine. The gut microbiota influences methionine metabolism, potentially impacting sulfur metabolite dysfunctions in CKD. We evaluated whether gut microbiota dysbiosis contributes to HS and lanthionine metabolic alterations in CKD.
View Article and Find Full Text PDFThe associations between gut microbiota and fecal metabolites with intelligence quotient in preschoolers.
BMC Microbiol
October 2024
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Article Synopsis
- The study explores the relationship between gut microbiota, fecal metabolites, and IQ levels in preschoolers, noting inconsistent findings in previous research.
- 150 children aged 3-6 were analyzed using 16 S rRNA sequencing and metabolomics, linking specific gut bacteria and metabolites to cognitive abilities as measured by the WPPSI-IV.
- Significant differences in microbial diversity and specific metabolites were found between children with low and average IQ, suggesting that gut health might influence cognitive development.
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