Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants. | LitMetric

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Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants. | LitMetric

Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.

Miyuki Kumano Masaya Fujita Kouji Nakamura Makiko Murata Reiko Ohki Kunio Yamane

Antimicrob Agents Chemother

Institute of Biological Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki 305-8572, Japan.

Published: January 2003

We isolated 19 lincomycin-resistant Bacillus subtilis mutants by expressing lmrB encoding a putative multidrug efflux protein. Eighteen of the mutants altered at two regions (-3 to -1 and +15) immediately downstream of the -10 region of the lmr promoter increased lmr transcription in vivo and in vitro.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC148993	PMC
http://dx.doi.org/10.1128/AAC.47.1.432-435.2003	DOI Listing

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