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N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
Amino Acids
September 2022
Clinic for Rheumatology und Immunology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
N-Acetyl-L-cysteine (NAC) is an endogenous cysteine metabolite. The drug is widely used in chronic obstructive pulmonary disease (COPD) and as antidote in acetaminophen (paracetamol) intoxication. Currently, the utility of NAC is investigated in rheumatoid arthritis (RA), which is generally considered associated with inflammation and oxidative stress.
View Article and Find Full Text PDFSystematic review on women's values and preferences concerning breast cancer screening and diagnostic services.
Psychooncology
May 2019
Biomedical Research Institute (IIB Sant Pau), Iberoamerican Cochrane Centre, Barcelona, Spain.
Article Synopsis
- - Women's preferences are key in shaping breast cancer screening guidelines, especially given the mixed views on its benefits versus harms.
- - A systematic review of 22 studies revealed that women are willing to endure the mental and physical challenges of screening for the chance of an earlier diagnosis, despite risks of overdiagnosis and false positives.
- - There is a significant emphasis on the need for quicker testing and better communication since the delay in getting results is a major source of anxiety for women, highlighting that while they value early diagnosis, understanding the risks like overdiagnosis remains a concern.
Aim: To study effects of pharmaceutical products on the results of clinical and laboratory diagnostics.
Materials And Methods: The list of vitally important pharmaceuticals, clinico-pharmacological articles of the National registry of medicinal products, formulary articles from the Federal guidelines on the use of pharmaceutical products. Formulary system, instructions for use of individual pharmaceutical products.
[Effect of thymoleptics in aspects of new clinical systematics of depressive syndrome].
Zh Nevrol Psikhiatr Im S S Korsakova
May 1998
Analysis of present concepts of clinico-pharmacological correlations in depression shows the necessity of search for new approaches to the problem. The original clinical model of depression, based on the idea of positive and negative affectivity in its structure is discussed. When applied to therapeutical strategy these principals elucidate new clinical signs for choice of appropriate class of antidepressants.
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