Aim: To study bronchial reactivity and sensitivity with consideration of histamine, serotonin and catecholamines concentration in bronchial mucosa in patients with acute bronchitis (AB) as possible criteria of its becoming chronic.
Material And Methods: Before the treatment 116 patients with verified AB were examined using inhalation provocative tests (IPT) with histamine, serotonin and obsidian in increasing doses. Also, external respiration function was studied. IPT were repeated after the course of treatment.
Results: 87 of 116 AB patients exhibited high bronchial sensitivity and reactivity to inhalations of histamine, serotonin, obsidian. In parallel, there was a rise in the levels of histamine and serotonin and a fall in the level of catecholamines in bronchial mucosa (alveolar macrophages, lymphocytes, neutrophils, mast and APUD-cells). Changes in monoamines concentration in bronchial mucosa were relevant to activity of bronchial inflammation and the presence of obstructive syndrome.
Conclusion: Persistent bronchial hyperreactivity to inhalations of histamine and obsidian along with high histamine levels and low level of catecholamines in alveolar macrophages, lymphocytes and mucus is a criterion of bronchitis transformation to chronic one.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Sleeve gastrectomy reveals the plasticity of the human gastric epithelium.
Nat Commun
January 2025
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gastrin is secreted following a rise in gastric pH, leading to gastric acid secretion. Sleeve gastrectomy (SG), a bariatric surgery where 80% of the gastric corpus is excised, presents a challenge for gastric pH homeostasis. Using histology, and single-cell RNA sequencing of the gastric epithelium in 12 women, we observed that SG is associated with an increase in a sub-population of acid-secreting parietal cells that overexpress respiratory enzymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs).
View Article and Find Full Text PDFPersistent pollutant exposure impacts metabolomic profiles in polar bears and ringed seals from the High Arctic and Hudson Bay, Canada.
Environ Res
January 2025
Environment and Climate Change Canada, Ecotoxicology and Wildlife Health Division, National Wildlife Research Centre, Carleton University, Ottawa, ON, K1A 0H3, Canada. Electronic address:
Metabolomics measures low molecular weight endogenous metabolites and changes linked to contaminant exposure in biota. Few studies have explored the relationship between metabolomics and contaminants in Arctic wildlife. We analyzed 239 endogenous metabolites and ∼150 persistent organic pollutants (POPs), including total mercury (THg), in the liver of polar bears and their ringed seal prey harvested from low Canadian Arctic (western Hudson Bay; WHB) and high Arctic (HA) locations during 2015-2016.
View Article and Find Full Text PDFAstragaloside IV Relieves Central Sensitization by Regulating Astrocytic ROS/NF-κB Nuclear Translocation Signaling in Chronic Migraine Male Rats.
Phytother Res
January 2025
Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chronic migraine (CM) is a disabling neurological disease. Astragaloside IV (AS-IV), a natural product derived from Astragalus membranaceus, shows great potential in treating chronic pain by relieving inflammation and oxidative stress. This study aimed to investigate the effects and mechanisms of action of AS-IV on CM.
View Article and Find Full Text PDFMolecular Mechanisms of Rett Syndrome: Emphasizing the Roles of Monoamine, Immunity, and Mitochondrial Dysfunction.
Cells
December 2024
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rett syndrome (RTT), which predominantly affects females, arises in most cases from mutations in the () gene. When MeCP2 is impaired, it disrupts the regulation of numerous genes, causing the production of dysfunctional proteins associated with various multi-systemic issues in RTT. In this review, we explore the current insights into molecular signaling related to monoamines, immune response, and mitochondrial function, and their implications for the pathophysiology of RTT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!