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Background: Congenital ichthyoses are a rare Mendelian group of disorders affecting the integument with a heterogeneous clinical presentation amongst which scaling is a constant feature. There is scanty epidemiologic data regarding the clinical profile and histologic patterns of inherited ichthyosis from resource-poor countries.

Aims And Objectives: The study was aimed at assessing the clinic-epidemiologic characteristics associated with the different forms of non-syndromic congenital ichthyosis.

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We update results from the Mycotic Infections in COVID-19 (MUNCO) Registry, May-September 2021. Data collection from May to September 2021 yielded 728 cases from India, Nepal, Bangladesh, Thailand, and the United States. The cases consisted of mostly mucormycosis (97.

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Introduction: Analyzing longitudinal cancer quality-of-life (QoL) measurements and their impact on clinical outcomes may improve our understanding of patient trajectories during systemic therapy. We applied an unsupervised growth mixture modeling (GMM) approach to identify unobserved subpopulations ("patient clusters") in the CO.20 clinical trial longitudinal QoL data.

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Article Synopsis
  • Researchers evaluated the effectiveness of restriction spectrum imaging (RSI-MRI) as a biomarker for predicting upgrading in prostate cancer patients undergoing active surveillance (AS) biopsies.
  • The study involved men who received MRI scans and 30 different biomarkers, analyzing their potential to predict reclassification on subsequent biopsies from January 2016 to June 2019.
  • RSI-MRI outperformed other non-imaging biomarkers, showing the highest prediction accuracy (AUC = 0.84), indicating its potential to enhance decision-making in AS protocols.
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Purpose: To elucidate the clinico-epidemiologic characteristics of optic neuritis based on the status of serum aquaporin-4 antibody (AQP4-Ab) in patients with optic neuritis (ON).

Methods: Medical records of 106 patients with ON and a follow-up of 3 years were reviewed. For each patient, the following data were extracted: medical history, findings of the ocular examination, brain, orbital or spinal MRI, and serological tests for AQP4.

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