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Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice.
Basic Res Cardiol
December 2024
Cedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
TY1, a synthetic non-coding RNA (ncRNA) bioinspired by small Y RNAs abundant in extracellular vesicles (EVs), decreases cGAS/STING activation in myocardial infarction and thereby attenuates inflammation. Motivated by the concept that heart failure with preserved ejection fraction (HFpEF) is a systemic inflammatory disease, we tested TY1 in a murine model of HFpEF. Intravenous TY1, packaged in a transfection reagent, reversed the cardiac and systemic manifestations of HFpEF in two-hit obese-hypertensive mice, without inducing weight loss.
View Article and Find Full Text PDFUseful or merely convenient? On the issue of a suitability of enzymatic antioxidant activity as a proxy for abiotic stress tolerance.
J Exp Bot
December 2024
School of Biological Sciences, The University of Western Australia, Perth, WA 6009, Australia.
During their lifespan, plants are often exposed to a broad range of stresses that change their redox balance and lead to accumulation of reactive oxygen species (ROS). The traditional view is that this comes with negative consequences to cells structural integrity and metabolism and, to prevent this, plants evolved a complex and well-coordinated antioxidant defence system that relies on the operation of a range of enzymatic and non-enzymatic antioxidants (AO). Due to the simplicity of measuring their activity, and in the light of the persistent dogma that stress-induced ROS accumulation is detrimental for plants, it is not surprising that enzymatic AO have often been advocated as suitable proxies for stress tolerance, as well as potential targets for improving tolerance traits.
View Article and Find Full Text PDFMasticatory Stress Maintains Mucosal Homeostasis via M2 Polarization.
J Dent Res
December 2024
Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Mastication not only helps in breaking down food but also plays a vital role in healing oral tissue by balancing damage and repair mechanisms.
- Research showed that mice on a soft food diet healed more slowly from oral wounds compared to those on a hard food diet, suggesting that masticatory stress is important for tissue repair.
- The study found that reduced masticatory stress led to lower expression of key genes involved in healing and macrophage activity, indicating the significance of physical stimulation in enhancing immune responses and wound healing in oral tissues.
Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischaemia reperfusion injury requires VEGFR2 signalling.
Am J Physiol Lung Cell Mol Physiol
December 2024
School of Medicine and Conway Institute, University College Dublin, Dublin, Ireland.
Normal shear stress produced by blood flow is sensed by the vascular endothelium and required for maintenance of the homeostatic functions of the endothelium in systemic conduit and resistance vessels. Many critical illnesses are characterised by periods of abnormally reduced or absent shear stress in the lung (e.g.
View Article and Find Full Text PDFMagnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways.
Nutrients
December 2024
Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Background: Rheumatoid arthritis (RA) is a common systemic autoimmune inflammatory disease that can cause joint damage. We have recently reported that oral magnesium supplementation significantly reduces disease severity and joint damage in models of RA.
Methods: In the present study, we analyzed the transcriptome of spleens and synovial tissues obtained from mice with KRN serum-induced arthritis (KSIA) consuming either a high Mg supplemented diet (Mg2800; n = 7) or a normal diet (Mg500; n = 7).
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