Long-term limitation of motor activity of male rats is accompanied by impairments of mitochondrial ADP phosphorylation in liver and heart. The most significant changes were observed after 15 and 45 days of hypokinesia. Administration of GABA and pyracetam to animals subjected to hypokinesia induced a tendency to "normalization" of ADP phosphorilation processes.
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Molecules
October 2024
Centro Atlántico del Medicamento S.A. (CEAMED S.A.), PCTT, 38200 La Laguna, Tenerife, Spain.
Pharmaceutical and veterinary products are a class of contaminants of emerging concern, and their presence in the environment is due to continuous and incorrect disposal. Environmental scientists have been accumulating data on their adverse effects on animal populations since toxicological effects on wildlife were first published. Therefore, recycling strategies are needed.
View Article and Find Full Text PDFMolecules
August 2024
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Degenerative conditions, such as neurodegenerative disorders (Alzheimer's disease (AD), Parkinson's disease (PD)) and cardiovascular diseases, are complex, multifactorial disorders whose pathophysiology has not been fully elucidated yet. As a result, the available treatment options cannot eliminate these diseases radically, but only alleviate the symptoms. Both inflammatory processes and oxidation are key factors in the development and evolution of neurodegeneration, while acetylcholinesterase inhibitors are the most used therapeutic options against AD.
View Article and Find Full Text PDFEpilepsy Behav
April 2022
Department of Psychology, University of Yaoundé I, P.O. Box 755, Yaoundé, Cameroon.
Background: Epilepsy is a neurological disorder characterized by spontaneous recurrent seizures. Lantana camara (Verbenaceae) is a plant used in Cameroonian traditional medicine to treat dementia, epilepsy, and sleeping disorders. Hence, this study aimed to assess the antiepileptic-like effects of an aqueous extract of L.
View Article and Find Full Text PDFJ Food Biochem
May 2022
Food Quality Assurance Division, Defense Food Research Laboratory (DRDO), Mysore, India.
This study is focused on potential effects of ginsenosides from Panax ginseng (PG) against amnesic shell fish poison, that is, domoic acid-induced excitotoxicity. Mice received PG at two different dosages by oral feeding for a period of 28 days (50 and 100 mg kg bwt. ).
View Article and Find Full Text PDFCurr Res Pharmacol Drug Discov
September 2021
Shri Ram Institute of Technology-Jabalpur, Madhya, Pradesh, India.
Alzheimer's disease is a cerebrovascular disorder characterized by progressive loss of the mental capabilities. The novel therapeutic agent piracetam is a cyclic derivative of γ-aminobutyric acid and one of the oldest recognized synthetic nootropics. Piracetam improves cognitive function without stimulation or sedation.
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