AI Article Synopsis
- OCD is a common anxiety disorder that may be linked to variations in the dopamine receptor type 4 (DRD4) gene, specifically a 48-base pair polymorphism.
- A family-based study of 55 trios showed that the allele 2 of the DRD4 gene is significantly less transmitted to OCD patients, indicating a potential protective effect.
- Additionally, population-based research confirmed a lower frequency of allele 2 in OCD patients versus controls, with no association found in those with comorbid tics.
Article Abstract
Obsessive-compulsive disorder (OCD) is a frequent and disabling anxiety disorder. Dopamine (DA) might be involved in its pathophysiology, therefore DA receptors are candidate genes in OCD. A 48-base pairs (bp) polymorphism located in the third exon of the dopamine receptor type 4 (DRD4) gene has been described. Previous case control studies, however, have reported inconclusive results in OCD. The aim of the study was to study this polymorphism in a family-based association study of 55 trios. Extended transmission-disequilibrium test (ETDT) for preferential allele transmission in this group showed an absence of transmission of the allele 2 for the 48 bp repeat polymorphism of the DRD4 gene (P = 0.005). Moreover, in a population-based association study, we found a significantly lower frequency of the allele 2 in patients suffering from OCD compared to ethnically-matched controls (P = 0.02). We found no association of DRD4 48 bp polymorphism with OCD in the subgroup of patients with comorbid tics. This study is the first to report on a significant association of variants of the DRD4 gene in OCD, found on both family- and population-based studies. The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms.
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| http://dx.doi.org/10.1002/ajmg.b.10034 | DOI Listing |
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