AI Article Synopsis
- Cytokine signals play a crucial role in the homeostasis of CD8+ memory T cells, but the specific mechanisms were not well understood until now.
- Research shows that mice lacking Stat5 proteins (Stat5a and Stat5b KO) have fewer CD8+ T cells, while mice with additional Stat5 (transgenic mice) have more of these cells due to enhanced cell survival and proliferation.
- The study identifies Stat5 proteins as key regulators in how cytokines influence the balance and maintenance of CD8+ memory T cells, highlighting their importance in immune responses.
Article Abstract
Cytokine signals are known to contribute to CD8+ memory T cell homeostasis, but an exact understanding of the mechanism(s) has remained elusive. We have now investigated the role of Stat5 proteins in this process. Whereas Stat5a and Stat5b KO mice have decreased numbers of CD8+ T cells, Stat5-transgenic mice have an increased number of these cells. Stat5b-transgenic mice exhibit increased Ag-induced cell death of CD4+ T cells and augmented proliferation and Bcl-2 expression in CD8+ T cells, providing a basis for this finding. Moreover, CD8+ memory T cells are substantially affected by Stat5 levels. These findings identify Stat5 proteins as critical signaling mediators used by cytokines to regulate CD8+ T cell homeostasis.
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| http://dx.doi.org/10.4049/jimmunol.170.1.210 | DOI Listing |
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