Objectives: The aim of the study was to evaluate the incidence and the risk factors of heterotopic ossifications in patients with severe traumatic brain injury.
Material And Methods: This retrospective study was conducted in a sample of 86 patients during a two years period. These patients were receiving care in an acute rehabilitation setting designed for traumatic brain injury patients emerging from coma. The statistical analysis used chi(2) and Fisher tests.
Results, Discussion: Forty-nine heterotopic ossifications were observed in 24 patients (incidence 28.57%, 2.04/patient). Most of them were localised at the level of the hip, of the elbow and of the knee. No significant relation was found between heterotopic ossification and sex, age, clinical severity, motor impairment, spasticity or autonomic dysreflexia. On the contrary, associated limb fractures, specially when requiring a surgical treatment, were found to be correlated to a greater incidence of heterotopic ossification.
Conclusion: Some of the risk factors observed in the present study were in accordance with those previously described in the literature. This work shows the difficult place of the initial care of patients with severe traumatic brain injury specially during there stay in intensive care units.
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http://dx.doi.org/10.1016/s0168-6054(02)00305-7 | DOI Listing |
Funct Integr Genomics
January 2025
Department of Radiology, The Second Xiangya Hospital of Central South University, No. 139, Renmin Middle Road, Furong District, Changsha City, Hunan Province, 410011, China.
Post-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI). Although FTO has been reported as a possible intervention target of TBI, its precise roles in the PTE remain incompletely understood. Here we used mild or serious mice TBI model to probe the role and molecular mechanism of FTO in PTE.
View Article and Find Full Text PDFPLoS One
January 2025
Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Background: Posttraumatic stress disorder (PTSD) affects 3.9% of the general population. While massed cognitive processing therapy (CPT) has demonstrated efficacy in treating chronic PTSD, a substantial proportion of patients still continue to meet PTSD criteria after treatment, highlighting the need for novel therapeutic approaches.
View Article and Find Full Text PDFJ Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopaedic Surgery, Foot and Ankle Research and Innovation Laboratory (FARIL), Massachusetts General Hospital, Harvard Medical School, Boston, MA (Flaherty, Ghandour, Mirochnik, Lucaciu, Nassour, Kwon, and Ashkani-Esfahani); the Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Kwon, Harris, and Ashkani-Esfahani); and the Department of Orthopaedic Surgery, Massachusetts General Hospital, Division Foot and Ankle, Harvard Medical School, Boston, MA (Kwon and Ashkani-Esfahani).
Background: Approximately 25% of children in the United States experience child abuse or neglect, 18% of whom are physically abused. Physicians are often in a position to differentiate accidental trauma from physical child abuse. Therefore, the aim of this study was to review recent literature for risk factors associated with physical child abuse.
View Article and Find Full Text PDFFree Neuropathol
January 2024
Department of Pathology, Nash Family Department of Neuroscience, Department of Artificial Intelligence & Human Health, Neuropathology Brain Bank & Research CoRE, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
This review highlights a collection of both diverse and highly impactful studies published in the previous year selected by the author from the neurodegenerative neuropathology literature. As with previous reviews in this series, the focus is, to the best of my ability, to highlight human tissue-based experimentation most relevant to experimental and clinical neuropathologists. A concerted effort was made to balance the selected studies across neurodegenerative disease categories, approaches, and methodologies to capture the breadth of the research landscape.
View Article and Find Full Text PDFInt J Clin Health Psychol
October 2024
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Individuals often actively suppress intrusive memories to alleviate the distress they cause and maintain mental well-being. However, those with post-traumatic stress disorder (PTSD) often exhibit difficulties particularly in inhibiting or suppressing negative memories compared to individuals without PTSD. These memories can involve a physical threat either to the individual themselves or to others.
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